Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA

One of the most promising new targets for trypanocidal drugs to emerge in recent years is the cyclic AMP (cAMP) phosphodiesterase (PDE) activity encoded by TbrPDEB1 and TbrPDEB2. These genes were genetically confirmed as essential, and a high-affinity inhibitor, CpdA, displays potent antitrypanosoma...

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Hlavní autoři: Gould, Matthew K., Bachmaier, Sabine, Ali, Juma A. M., Alsford, Sam, Tagoe, Daniel N. A., Munday, Jane C., Schnaufer, Achim C., Horn, David, Boshart, Michael, de Koning, Harry P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811416/
https://ncbi.nlm.nih.gov/pubmed/23877697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00508-13
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