Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA

One of the most promising new targets for trypanocidal drugs to emerge in recent years is the cyclic AMP (cAMP) phosphodiesterase (PDE) activity encoded by TbrPDEB1 and TbrPDEB2. These genes were genetically confirmed as essential, and a high-affinity inhibitor, CpdA, displays potent antitrypanosoma...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Gould, Matthew K., Bachmaier, Sabine, Ali, Juma A. M., Alsford, Sam, Tagoe, Daniel N. A., Munday, Jane C., Schnaufer, Achim C., Horn, David, Boshart, Michael, de Koning, Harry P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811416/
https://ncbi.nlm.nih.gov/pubmed/23877697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00508-13
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge