The Cullin3 Ubiquitin Ligase Functions as a Nedd8-bound Heterodimer

Por Wimuttisuk, Wananit, Singer, Jeffrey D.
Publicado em 2007

The Ubiquitin Conjugating Enzyme, UbcM2, Engages in Novel Interactions with Components of Cullin-3 Based E3 Ligases

Por Plafker, Kendra S., Singer, Jeffrey D., Plafker, Scott M.
Publicado em 2009

BTB-Kelch Proteins and Ubiquitination of Kainate Receptors

Por Marshall, John, Blair, Leslie A.C., Singer, Jeffrey D.
Publicado em 2011

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

Por Singer, Jeffrey D., Gurian-West, Mark, Clurman, Bruce, Roberts, James M.
Publicado em 1999

Constitutive Turnover of Cyclin E by Cul3 Maintains Quiescence

Por McEvoy, Justina D., Kossatz, Uta, Malek, Nisar, Singer, Jeffrey D.
Publicado em 2007

Novel Cul3 binding proteins function to remodel E3 ligase complexes

Por Wimuttisuk, Wananit, West, Mark, Davidge, Brittney, Yu, Kebing, Salomon, Arthur, Singer, Jeffrey D
Publicado em 2014

The Cul3/Klhdc5 E3 Ligase Regulates p60/Katanin and Is Required for Normal Mitosis in Mammalian Cells

Por Cummings, Cristina M., Bentley, Cornelia A., Perdue, Sarah A., Baas, Peter W., Singer, Jeffrey D.
Publicado em 2009

B-Myb promotes S-phase independently of its sequence-specific DNA binding activity and interacts with polymerase delta-interacting protein 1 (Pdip1)

Por Werwein, Eugen, Schmedt, Thore, Hoffmann, Heiko, Usadel, Clemens, Obermann, Nora, Singer, Jeffrey D., Klempnauer, Karl-Heinz
Publicado em 2012

Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice

Por Claiborn, Kathryn C., Sachdeva, Mira M., Cannon, Corey E., Groff, David N., Singer, Jeffrey D., Stoffers, Doris A.
Publicado em 2010

Amorphous Alumina Nanowire Array Efficiently Delivers Ac-DEVD-CHO to Inhibit Apoptosis of Dendritic Cells

Por Lampert, Lester, Timonen, Brittany, Smith, Sean, Davidge, Brittney, Li, Haiyan, Conley, John F., Singer, Jeffrey D., Jiao, Jun
Publicado em 2014

BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs

Por Mathew, Rebecca, Seiler, Michael P., Scanlon, Seth T., Mao, Aiping, Constantinides, Michael G., Bertozzi-Villa, Clara, Singer, Jeffrey D., Bendelac, Albert
Publicado em 2012

Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy

Por Israeli, Eitan, Dryanovski, Dilyan I., Schumacker, Paul T., Chandel, Navdeep S., Singer, Jeffrey D., Julien, Jean P., Goldman, Robert D., Opal, Puneet
Publicado no Hum Mol Genet (2016)

Designing Calcium Release Channel Inhibitors with Enhanced Electron Donor Properties: Stabilizing the Closed State of Ryanodine Receptor Type 1

Por Ye, Yanping, Yaeger, Daniel, Owen, Laura J., Escobedo, Jorge O., Wang, Jialu, Singer, Jeffrey D., Strongin, Robert M., Abramson, Jonathan J.
Publicado em 2012

Degradation by Cullin3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension

Por Zhang, Chong, Meermeier, Nicholas P., Terker, Andrew S., Blankenstein, Katharina I., Singer, Jeffrey D., Hadchouel, Juliette, Ellison, David H., Yang, Chao-Ling
Publicado no Biochem Biophys Res Commun (2015)

Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects

Por Ferdaus, Mohammed Z., Miller, Lauren N., Agbor, Larry N., Saritas, Turgay, Singer, Jeffrey D., Sigmund, Curt D., McCormick, James A.
Publicado no JCI Insight (2017)

Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation

Por Li, Xinghui, Zhang, Zhibin, Li, Lupeng, Gong, Wei, Lazenby, Audrey J., Swanson, Benjamin J., Herring, Laura E., Asara, John M., Singer, Jeffrey D., Wen, Haitao
Publicado no J Exp Med (2017)

The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells

Por Kossatz, Uta, Breuhahn, Kai, Wolf, Benita, Hardtke-Wolenski, Matthias, Wilkens, Ludwig, Steinemann, Doris, Singer, Stephan, Brass, Felicitas, Kubicka, Stefan, Schlegelberger, Brigitte, Schirmacher, Peter, Manns, Michael P., Singer, Jeffrey D., Malek, Nisar P.
Publicado em 2010

A negative feedback loop mediated by the Bcl6–cullin 3 complex limits Tfh cell differentiation

Por Mathew, Rebecca, Mao, Ai-ping, Chiang, Andrew H., Bertozzi-Villa, Clara, Bunker, Jeffrey J., Scanlon, Seth T., McDonald, Benjamin D., Constantinides, Michael G., Hollister, Kristin, Singer, Jeffrey D., Dent, Alexander L., Dinner, Aaron R., Bendelac, Albert
Publicado em 2014

Hyperkalemic hypertension–associated cullin 3 promotes WNK signaling by degrading KLHL3

Por McCormick, James A., Yang, Chao-Ling, Zhang, Chong, Davidge, Brittney, Blankenstein, Katharina I., Terker, Andrew S., Yarbrough, Bethzaida, Meermeier, Nicholas P., Park, Hae J., McCully, Belinda, West, Mark, Borschewski, Aljona, Himmerkus, Nina, Bleich, Markus, Bachmann, Sebastian, Mutig, Kerim, Argaiz, Eduardo R., Gamba, Gerardo, Singer, Jeffrey D., Ellison, David H.
Publicado no J Clin Invest (2014)