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Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy
Intermediate filaments (IFs) are cytoskeletal polymers that extend from the nucleus to the cell membrane, giving cells their shape and form. Abnormal accumulation of IFs is involved in the pathogenesis of number neurodegenerative diseases, but none as clearly as giant axonal neuropathy (GAN), a rava...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5081048/ https://ncbi.nlm.nih.gov/pubmed/27000625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw081 |
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