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Explaining intermediate filament accumulation in giant axonal neuropathy

Giant axonal neuropathy (GAN)(1) is a rare autosomal recessive neurological disorder caused by mutations in the GAN gene that encodes gigaxonin, a member of the BTB/Kelch family of E3 ligase adaptor proteins.(1) This disease is characterized by the aggregation of Intermediate Filaments (IF)—cytoskel...

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Autori principali: Opal, Puneet, Goldman, Robert D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927486/
https://ncbi.nlm.nih.gov/pubmed/25003002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rdis.25378
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