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Abnormal intermediate filament organization alters mitochondrial motility in giant axonal neuropathy fibroblasts
Giant axonal neuropathy (GAN) is a rare disease caused by mutations in the GAN gene, which encodes gigaxonin, an E3 ligase adapter that targets intermediate filament (IF) proteins for degradation in numerous cell types, including neurons and fibroblasts. The cellular hallmark of GAN pathology is the...
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| Publicado no: | Mol Biol Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4750921/ https://ncbi.nlm.nih.gov/pubmed/26700320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-09-0627 |
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