Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells

Yazar: Shah, Mittal, Maroof, Asher, Gikas, Panos, Mittal, Gayatri, Keen, Richard, Baeten, Dominique, Shaw, Stevan, Roberts, Scott J
Yayımlandı RMD Open (2020)

Interleukin (IL)-12 and IL-18 Synergize to Promote MAIT Cell IL-17A and IL-17F Production Independently of IL-23 Signaling

Yazar: Cole, Suzanne, Murray, Janine, Simpson, Catherine, Okoye, Remi, Tyson, Kerry, Griffiths, Meryn, Baeten, Dominique, Shaw, Stevan, Maroof, Asher
Yayımlandı Front Immunol (2020)

First‐in‐human randomized study of bimekizumab, a humanized monoclonal antibody and selective dual inhibitor of IL‐17A and IL‐17F, in mild psoriasis

Yazar: Glatt, Sophie, Helmer, Eric, Haier, Birgit, Strimenopoulou, Foteini, Price, Graham, Vajjah, Pavan, Harari, Olivier A., Lambert, John, Shaw, Stevan
Yayımlandı Br J Clin Pharmacol (2017)

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase

Yazar: Shan, Yibing, Gnanasambandan, Kavitha, Ungureanu, Daniela, Kim, Eric T., Hammarén, Henrik, Yamashita, Kazuo, Silvennoinen, Olli, Shaw, David E., Hubbard Shaw, Stevan R.
Yayımlandı Nat Struct Mol Biol (2014)

Collagen II antibody-induced arthritis in Tg1278TNFko mice: optimization of a novel model to assess treatments targeting human TNFα in rheumatoid arthritis

Yazar: Moore, Adrian Richard, Allden, Sarah, Bourne, Tim, Denis, Maria C, Kranidioti, Ksanthi, Okoye, Remi, Sotsios, Yannis, Stencel, Zofia, Vugler, Alexander, Watt, Gillian, Shaw, Stevan
Yayımlandı J Transl Med (2014)

Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Both IL-17A and IL-17F

Yazar: Adams, Ralph, Maroof, Asher, Baker, Terry, Lawson, Alastair D. G., Oliver, Ruth, Paveley, Ross, Rapecki, Steve, Shaw, Stevan, Vajjah, Pavan, West, Shauna, Griffiths, Meryn
Yayımlandı Front Immunol (2020)

Efficacy and safety of bimekizumab as add-on therapy for rheumatoid arthritis in patients with inadequate response to certolizumab pegol: a proof-of-concept study

Yazar: Glatt, Sophie, Taylor, Peter C, McInnes, Iain B, Schett, Georg, Landewé, Robert, Baeten, Dominique, Ionescu, Lucian, Strimenopoulou, Foteini, Watling, Mark I L, Shaw, Stevan
Yayımlandı Ann Rheum Dis (2019)

Interleukin-6 Contributes to Inflammation and Remodeling in a Model of Adenosine Mediated Lung Injury

Yazar: Pedroza, Mesias, Schneider, Daniel J., Karmouty-Quintana, Harry, Coote, Julie, Shaw, Stevan, Corrigan, Rebecca, Molina, Jose G., Alcorn, Joseph L., Galas, David, Gelinas, Richard, Blackburn, Michael R.
Baskı/Yayın Bilgisi 2011

Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling

Yazar: Shaw, Stevan, Bourne, Tim, Meier, Chris, Carrington, Bruce, Gelinas, Rich, Henry, Alistair, Popplewell, Andrew, Adams, Ralph, Baker, Terry, Rapecki, Steve, Marshall, Diane, Moore, Adrian, Neale, Helen, Lawson, Alastair
Baskı/Yayın Bilgisi 2014

OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis

Yazar: Gwyer Findlay, Emily, Danks, Lynett, Madden, Jodie, Cavanagh, Mary M., McNamee, Kay, McCann, Fiona, Snelgrove, Robert J., Shaw, Stevan, Feldmann, Marc, Taylor, Peter Charles, Horwood, Nicole J., Hussell, Tracy
Baskı/Yayın Bilgisi 2014

Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F co...

Yazar: Glatt, Sophie, Baeten, Dominique, Baker, Terry, Griffiths, Meryn, Ionescu, Lucian, Lawson, Alastair D G, Maroof, Ash, Oliver, Ruth, Popa, Serghei, Strimenopoulou, Foteini, Vajjah, Pavan, Watling, Mark I L, Yeremenko, Nataliya, Miossec, Pierre, Shaw, Stevan
Yayımlandı Ann Rheum Dis (2018)

CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study

Yazar: Shock, Anthony, Burkly, Linda, Wakefield, Ian, Peters, Christopher, Garber, Ellen, Ferrant, Janine, Taylor, Frederick R., Su, Lihe, Hsu, Yen-Ming, Hutto, David, Amirkhosravi, Ali, Meyer, Todd, Francis, John, Malcolm, Sarah, Robinson, Martyn, Brown, Derek, Shaw, Stevan, Foulkes, Roland, Lawson, Alastair, Harari, Olivier, Bourne, Timothy, Maloney, Alison, Weir, Neil
Yayımlandı Arthritis Res Ther (2015)

Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentr...

Yazar: Smith, Bryan, Kiessling, Andrea, Lledo-Garcia, Rocio, Dixon, Kate L., Christodoulou, Louis, Catley, Matthew C., Atherfold, Paul, D’Hooghe, Lena E., Finney, Helene, Greenslade, Kevin, Hailu, Hanna, Kevorkian, Lara, Lightwood, Daniel, Meier, Christoph, Munro, Rebecca, Qureshi, Omar, Sarkar, Kaushik, Shaw, Sophie P., Tewari, Roohi, Turner, Alison, Tyson, Kerry, West, Shauna, Shaw, Stevan, Brennan, Frank R.
Yayımlandı MAbs (2018)