Lipotoxicity in the Pancreatic Beta Cell: Not Just Survival and Function, but Proliferation as Well?

Por Sharma, Rohit B., Alonso, Laura C.
Publicado em 2014

Islet biology, the CDKN2A/B locus and type 2 diabetes risk

Por Kong, Yahui, Sharma, Rohit B., Nwosu, Benjamin U., Alonso, Laura C.
Publicado no Diabetologia (2016)

Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression

Por Stamateris, Rachel E., Sharma, Rohit B., Hollern, Douglas A., Alonso, Laura C.
Publicado em 2013

Insulin demand regulates β cell number via the unfolded protein response

Por Sharma, Rohit B., O’Donnell, Amy C., Stamateris, Rachel E., Ha, Binh, McCloskey, Karen M., Reynolds, Paul R., Arvan, Peter, Alonso, Laura C.
Publicado no J Clin Invest (2015)

Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor

Por Stamateris, Rachel E., Sharma, Rohit B., Kong, Yahui, Ebrahimpour, Pantea, Panday, Deepika, Ranganath, Pavana, Zou, Baobo, Levitt, Helena, Parambil, Nisha Abraham, O’Donnell, Christopher P., García-Ocaña, Adolfo, Alonso, Laura C.
Publicado no Diabetes (2016)

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia

Por Roth Flach, Rachel J., Danai, Laura V., DiStefano, Marina T., Kelly, Mark, Menendez, Lorena Garcia, Jurczyk, Agata, Sharma, Rohit B., Jung, Dae Young, Kim, Jong Hun, Kim, Jason K., Bortell, Rita, Alonso, Laura C., Czech, Michael P.
Publicado no J Biol Chem (2016)

In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy

Por Choudhury, Sourav R, Fitzpatrick, Zachary, Harris, Anne F, Maitland, Stacy A, Ferreira, Jennifer S, Zhang, Yuanfan, Ma, Shan, Sharma, Rohit B, Gray-Edwards, Heather L, Johnson, Jacob A, Johnson, Aime K, Alonso, Laura C, Punzo, Claudio, Wagner, Kathryn R, Maguire, Casey A, Kotin, Robert M, Martin, Douglas R, Sena-Esteves, Miguel
Publicado no Mol Ther (2016)