Src family kinases: at the forefront of platelet activation

Por Senis, Yotis A., Mazharian, Alexandra, Mori, Jun
Publicado em 2014

Perspective: Tyrosine Phosphatases As Novel Targets For Antiplatelet Therapy

Por Tautz, Lutz, Senis, Yotis A., Oury, Cécile, Rahmouni, Souad
Publicado no Bioorg Med Chem (2015)

A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter

Por García, Ángel, Senis, Yotis A., Antrobus, Robin, Hughes, Craig E., Dwek, Raymond A., Watson, Steve P., Zitzmann, Nicole
Publicado em 2006

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

Por Mazharian, Alexandra, Mori, Jun, Wang, Ying-Jie, Heising, Silke, Neel, Benjamin G., Watson, Steve P., Senis, Yotis A.
Publicado em 2013

G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2

Por Mori, Jun, Pearce, Andrew C., Spalton, Jennifer C., Grygielska, Beata, Eble, Johannes A., Tomlinson, Michael G., Senis, Yotis A., Watson, Steve P.
Publicado em 2008

Syk-dependent Phosphorylation of CLEC-2: A NOVEL MECHANISM OF HEM-IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIF SIGNALING

Por Séverin, Sonia, Pollitt, Alice Y., Navarro-Nuñez, Leyre, Nash, Craig A., Mourão-Sá, Diego, Eble, Johannes A., Senis, Yotis A., Watson, Steve P.
Publicado em 2011

MINIMAL REGULATION OF PLATELET ACTIVITY BY PECAM-1

Por Dhanjal, Tarvinder S., Ross, Ewan A., Auger, Jocelyn M., McCarty, Owen J.T., Hughes, Craig E., Senis, Yotis A., Buckley, Chris D., Watson, Steve P.
Publicado em 2007

Role of the p110δ PI 3-kinase in integrin and ITAM receptor signalling in platelets

Por Senis, Yotis A., Atkinson, Ben T., Pearce, Andrew C., Wonerow, Peter, Auger, Jocelyn M., Okkenhaug, Klaus, Pearce, Wayne, Vigorito, Elena, Vanhaesebroeck, Bart, Turner, Martin, Watson, Steve P.
Publicado em 2005

Global proteomic assessment of the classical protein-tyrosine phosphatome and “redoxome”

Por Karisch, Robert, Fernandez, Minerva, Taylor, Paul, Virtanen, Carl, St-Germain, Jonathan R., Jin, Lily L., Harris, Isaac S., Mori, Jun, Mak, Tak W., Senis, Yotis A., Östman, Arne, Moran, Michael F., Neel, Benjamin G.
Publicado em 2011

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

Por Senis, Yotis A., Tomlinson, Michael G., Ellison, Stuart, Mazharian, Alexandra, Lim, Jenson, Zhao, Yan, Kornerup, Kristin N., Auger, Jocelyn M., Thomas, Steve G., Dhanjal, Tarvinder, Kalia, Neena, Zhu, Jing W., Weiss, Arthur, Watson, Steve P.
Publicado em 2009

Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains

Por Protty, Majd B., Watkins, Nicholas A., Colombo, Dario, Thomas, Steven G., Heath, Victoria L., Herbert, John M. J., Bicknell, Roy, Senis, Yotis A., Ashman, Leonie K., Berditchevski, Fedor, Ouwehand, Willem H., Watson, Steve P., Tomlinson, Michael G.
Publicado em 2008

Mice Lacking the ITIM-Containing Receptor G6b-B Exhibit Macrothrombocytopenia and Aberrant Platelet Function

Por Mazharian, Alexandra, Wang, Ying-Jie, Mori, Jun, Bem, Danai, Finney, Brenda, Heising, Silke, Gissen, Paul, White, James G., Berndt, Michael C., Gardiner, Elizabeth E., Nieswandt, Bernhard, Douglas, Michael R., Campbell, Robert D., Watson, Steve P., Senis, Yotis A.
Publicado no Sci Signal (2012)

A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel ITIM protein

Por Senis, Yotis A., Tomlinson, Michael G., García, Ángel, Dumon, Stephanie, Heath, Victoria L., Herbert, John, Cobbold, Stephen P., Spalton, Jennifer C., Ayman, Sinem, Antrobus, Robin, Zitzmann, Nicole, Bicknell, Roy, Frampton, Jon, Authi, Kalwant, Martin, Ashley, Wakelam, Michael J.O., Watson, Stephen P.
Publicado em 2006