Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance

Por Savage, David B., Petersen, Kitt Falk, Shulman, Gerald I.
Publicado em 2007

Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis

Por Patel, Satish, Yang, Wei, Kozusko, Kristina, Saudek, Vladimir, Savage, David B.
Publicado em 2014

Human Frame Shift Mutations Affecting the Carboxyl Terminus of Perilipin Increase Lipolysis by Failing to Sequester the Adipose Triglyceride Lipase (ATGL) Coactivator AB-hydrolase-...

Por Gandotra, Sheetal, Lim, Koini, Girousse, Amandine, Saudek, Vladimir, O'Rahilly, Stephen, Savage, David B.
Publicado em 2011

Simple and effective exercise design for assessing in vivo mitochondrial function in clinical applications using (31)P magnetic resonance spectroscopy

Por Sleigh, Alison, Lupson, Victoria, Thankamony, Ajay, Dunger, David B., Savage, David B., Carpenter, T. Adrian, Kemp, Graham J.
Publicado no Sci Rep (2016)

(31)P magnetization transfer measurements of P(i)→ATP flux in exercising human muscle

Por Sleigh, Alison, Savage, David B., Williams, Guy B., Porter, David, Carpenter, T. Adrian, Brindle, Kevin M., Kemp, Graham J.
Publicado no J Appl Physiol (1985) (2016)

Truncation of POC1A associated with short stature and extreme insulin resistance

Por Chen, Jian-Hua, Segni, Maria, Payne, Felicity, Huang-Doran, Isabel, Sleigh, Alison, Adams, Claire, Savage, David B., O’Rahilly, Stephen, Semple, Robert K., Barroso, Inês
Publicado no J Mol Endocrinol (2015)

TCF7L2 Polymorphisms Modulate Proinsulin Levels and β-Cell Function in a British Europid Population

Por Loos, Ruth J.F., Franks, Paul W., Francis, Richard W., Barroso, Inês, Gribble, Fiona M., Savage, David B., Ong, Ken K., O'Rahilly, Stephen, Wareham, Nicholas J.
Publicado em 2007

Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Ol...

Por Finucane, Francis M., Sharp, Stephen J., Hatunic, Mensud, Sleigh, Alison, De Lucia Rolfe, Ema, Sayer, Avan Aihie, Cooper, Cyrus, Griffin, Simon J., Savage, David B., Wareham, Nicholas J.
Publicado em 2013

Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1–3

Por Rowe, Emily R., Mimmack, Michael L., Barbosa, Antonio D., Haider, Afreen, Isaac, Iona, Ouberai, Myriam M., Thiam, Abdou Rachid, Patel, Satish, Saudek, Vladimir, Siniossoglou, Symeon, Savage, David B.
Publicado no J Biol Chem (2016)

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

Por Petersen, Kitt Falk, Dufour, Sylvie, Savage, David B., Bilz, Stefan, Solomon, Gina, Yonemitsu, Shin, Cline, Gary W., Befroy, Douglas, Zemany, Laura, Kahn, Barbara B., Papademetris, Xenophon, Rothman, Douglas L., Shulman, Gerald I.
Publicado em 2007

Mitochondrial Oxidative Phosphorylation Is Impaired in Patients with Congenital Lipodystrophy

Por Sleigh, Alison, Stears, Anna, Thackray, Kerrie, Watson, Laura, Gambineri, Alessandra, Nag, Sath, Campi, V. Irene, Schoenmakers, Nadia, Brage, Soren, Carpenter, T. Adrian, Murgatroyd, Peter R., O'Rahilly, Stephen, Kemp, Graham J., Savage, David B.
Publicado em 2012

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2

Por Savage, David B., Choi, Cheol Soo, Samuel, Varman T., Liu, Zhen-Xiang, Zhang, Dongyan, Wang, Amy, Zhang, Xian-Man, Cline, Gary W., Yu, Xing Xian, Geisler, John G., Bhanot, Sanjay, Monia, Brett P., Shulman, Gerald I.
Publicado em 2006

Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes

Por Eiden, Michael, Koulman, Albert, Hatunic, Mensud, West, James A., Murfitt, Steven, Osei, Michael, Adams, Claire, Wang, Xinzhu, Chu, Yajing, Marney, Luke, Roberts, Lee D., O’Rahilly, Stephen, Semple, Robert K., Savage, David B., Griffin, Julian L.
Publicado no Genome Med (2015)

Continuous fat oxidation in acetyl–CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

Por Choi, Cheol Soo, Savage, David B., Abu-Elheiga, Lutfi, Liu, Zhen-Xiang, Kim, Sheene, Kulkarni, Ameya, Distefano, Alberto, Hwang, Yu-Jin, Reznick, Richard M., Codella, Roberto, Zhang, Dongyan, Cline, Gary W., Wakil, Salih J., Shulman, Gerald I.
Publicado em 2007

Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial

Por Sharp Stephen J, Sleigh Alison, Rolfe Ema, Horton Kenneth, Besson Hervé, Brage Soren, Savage David B, Purslow Lisa R, Horton Jessica, Finucane Francis M, Martin Helen J, Sayer Avan, Cooper Cyrus, Ekelund Ulf, Griffin Simon J, Wareham Nicholas J
Publicado em 2009-06-01

Perilipin Deficiency and Autosomal Dominant Partial Lipodystrophy

Por Gandotra, Sheetal, Le Dour, Caroline, Bottomley, William, Cervera, Pascale, Giral, Philippe, Reznik, Yves, Charpentier, Guillaume, Auclair, Martine, Delépine, Marc, Barroso, Inês, Semple, Robert K., Lathrop, Mark, Lascols, Olivier, Capeau, Jacqueline, O’Rahilly, Stephen, Magré, Jocelyne, Savage, David B., Vigouroux, Corinne
Publicado em 2011

Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis

Por Semple, Robert K., Sleigh, Alison, Murgatroyd, Peter R., Adams, Claire A., Bluck, Les, Jackson, Sarah, Vottero, Alessandra, Kanabar, Dipak, Charlton-Menys, Valentine, Durrington, Paul, Soos, Maria A., Carpenter, T. Adrian, Lomas, David J., Cochran, Elaine K., Gorden, Phillip, O’Rahilly, Stephen, Savage, David B.
Publicado em 2009

Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial

Por Finucane, Francis M, Horton, Jessica, Purslow, Lisa R, Savage, David B, Brage, Soren, Besson, Hervé, Horton, Kenneth, Rolfe, Ema De Lucia, Sleigh, Alison, Sharp, Stephen J, Martin, Helen J, Sayer, Avan Aihie, Cooper, Cyrus, Ekelund, Ulf, Griffin, Simon J, Wareham, Nicholas J
Publicado em 2009

Mitochondrial dysfunction in patients with primary congenital insulin resistance

Por Sleigh, Alison, Raymond-Barker, Philippa, Thackray, Kerrie, Porter, David, Hatunic, Mensud, Vottero, Alessandra, Burren, Christine, Mitchell, Catherine, McIntyre, Martin, Brage, Soren, Carpenter, T. Adrian, Murgatroyd, Peter R., Brindle, Kevin M., Kemp, Graham J., O’Rahilly, Stephen, Semple, Robert K., Savage, David B.
Publicado em 2011

Early Diagnosis of Werner's Syndrome Using Exome-Wide Sequencing in a Single, Atypical Patient

Por Raffan, Eleanor, Hurst, Liam A., Turki, Saeed Al, Carpenter, Gillian, Scott, Carol, Daly, Allan, Coffey, Alison, Bhaskar, Sanjeev, Howard, Eleanor, Khan, Naz, Kingston, Helen, Palotie, Aarno, Savage, David B., O'Driscoll, Mark, Smith, Claire, O'Rahilly, Stephen, Barroso, Inês, Semple, Robert K.
Publicado em 2011