Laboratory Evolution to Alternating Substrate Environments Yields Distinct Phenotypic and Genetic Adaptive Strategies

Por Sandberg, Troy E., Lloyd, Colton J., Palsson, Bernhard O., Feist, Adam M.
Publicado no Appl Environ Microbiol (2017)

The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology

Por Sandberg, Troy E., Salazar, Michael J., Weng, Liam L., Palsson, Bernhard O., Feist, Adam M.
Publicado no Metab Eng (2019)

Evolution of E. coli on [U-(13)C]Glucose Reveals a Negligible Isotopic Influence on Metabolism and Physiology

Por Sandberg, Troy E., Long, Christopher P., Gonzalez, Jacqueline E., Feist, Adam M., Antoniewicz, Maciek R., Palsson, Bernhard O.
Publicado no PLoS One (2016)

Growth Adaptation of gnd and sdhCB Escherichia coli Deletion Strains Diverges From a Similar Initial Perturbation of the Transcriptome

Por McCloskey, Douglas, Xu, Sibei, Sandberg, Troy E., Brunk, Elizabeth, Hefner, Ying, Szubin, Richard, Feist, Adam M., Palsson, Bernhard O.
Publicado no Front Microbiol (2018)

Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism

Por McCloskey, Douglas, Xu, Sibei, Sandberg, Troy E., Brunk, Elizabeth, Hefner, Ying, Szubin, Richard, Feist, Adam M., Palsson, Bernhard O.
Publicado no Nat Commun (2018)

Multiple Optimal Phenotypes Overcome Redox and Glycolytic Intermediate Metabolite Imbalances in Escherichia coli pgi Knockout Evolutions

Por McCloskey, Douglas, Xu, Sibei, Sandberg, Troy E., Brunk, Elizabeth, Hefner, Ying, Szubin, Richard, Feist, Adam M., Palsson, Bernhard O.
Publicado no Appl Environ Microbiol (2018)

Evolution of Escherichia coli to 42 °C and Subsequent Genetic Engineering Reveals Adaptive Mechanisms and Novel Mutations

Por Sandberg, Troy E., Pedersen, Margit, LaCroix, Ryan A., Ebrahim, Ali, Bonde, Mads, Herrgard, Markus J., Palsson, Bernhard O., Sommer, Morten, Feist, Adam M.
Publicado em 2014

Use of Adaptive Laboratory Evolution To Discover Key Mutations Enabling Rapid Growth of Escherichia coli K-12 MG1655 on Glucose Minimal Medium

Por LaCroix, Ryan A., Sandberg, Troy E., O'Brien, Edward J., Utrilla, Jose, Ebrahim, Ali, Guzman, Gabriela I., Szubin, Richard, Palsson, Bernhard O., Feist, Adam M.
Publicado no Appl Environ Microbiol (2014)

Laboratory evolution reveals a two-dimensional rate-yield tradeoff in microbial metabolism

Por Cheng, Chuankai, O’Brien, Edward J., McCloskey, Douglas, Utrilla, Jose, Olson, Connor, LaCroix, Ryan A., Sandberg, Troy E., Feist, Adam M., Palsson, Bernhard O., King, Zachary A.
Publicado no PLoS Comput Biol (2019)

OxyR Is a Convergent Target for Mutations Acquired during Adaptation to Oxidative Stress-Prone Metabolic States

Por Anand, Amitesh, Chen, Ke, Catoiu, Edward, Sastry, Anand V, Olson, Connor A, Sandberg, Troy E, Seif, Yara, Xu, Sibei, Szubin, Richard, Yang, Laurence, Feist, Adam M, Palsson, Bernhard O
Publicado no Mol Biol Evol (2020)

The genetic basis for adaptation of model-designed syntrophic co-cultures

Por Lloyd, Colton J., King, Zachary A., Sandberg, Troy E., Hefner, Ying, Olson, Connor A., Phaneuf, Patrick V., O’Brien, Edward J., Sanders, Jon G., Salido, Rodolfo A., Sanders, Karenina, Brennan, Caitriona, Humphrey, Gregory, Knight, Rob, Feist, Adam M.
Publicado no PLoS Comput Biol (2019)

Enzyme promiscuity shapes adaptation to novel growth substrates

Por Guzmán, Gabriela I, Sandberg, Troy E, LaCroix, Ryan A, Nyerges, Ákos, Papp, Henrietta, de Raad, Markus, King, Zachary A, Hefner, Ying, Northen, Trent R, Notebaart, Richard A, Pál, Csaba, Palsson, Bernhard O, Papp, Balázs, Feist, Adam M
Publicado no Mol Syst Biol (2019)

Cellular responses to reactive oxygen species are predicted from molecular mechanisms

Por Yang, Laurence, Mih, Nathan, Anand, Amitesh, Park, Joon Ho, Tan, Justin, Yurkovich, James T., Monk, Jonathan M., Lloyd, Colton J., Sandberg, Troy E., Seo, Sang Woo, Kim, Donghyuk, Sastry, Anand V., Phaneuf, Patrick, Gao, Ye, Broddrick, Jared T., Chen, Ke, Heckmann, David, Szubin, Richard, Hefner, Ying, Feist, Adam M., Palsson, Bernhard O.
Publicado no Proc Natl Acad Sci U S A (2019)