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Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism

Biological regulatory network architectures are multi-scale in their function and can adaptively acquire new functions. Gene knockout (KO) experiments provide an established experimental approach not just for studying gene function, but also for unraveling regulatory networks in which a gene and its...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: McCloskey, Douglas, Xu, Sibei, Sandberg, Troy E., Brunk, Elizabeth, Hefner, Ying, Szubin, Richard, Feist, Adam M., Palsson, Bernhard O.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143558/
https://ncbi.nlm.nih.gov/pubmed/30228271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06219-9
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