Evolution of Escherichia coli to 42 °C and Subsequent Genetic Engineering Reveals Adaptive Mechanisms and Novel Mutations

Adaptive laboratory evolution (ALE) has emerged as a valuable method by which to investigate microbial adaptation to a desired environment. Here, we performed ALE to 42 °C of ten parallel populations of Escherichia coli K-12 MG1655 grown in glucose minimal media. Tightly controlled experimental cond...

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Autores principales: Sandberg, Troy E., Pedersen, Margit, LaCroix, Ryan A., Ebrahim, Ali, Bonde, Mads, Herrgard, Markus J., Palsson, Bernhard O., Sommer, Morten, Feist, Adam M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
Materias:
Discoveries
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166923/
https://ncbi.nlm.nih.gov/pubmed/25015645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msu209
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