Preclinical progression of neurodegenerative diseases

gan Katsuno, Masahisa, Sahashi, Kentaro, Iguchi, Yohei, Hashizume, Atsushi
Cyhoeddwyd yn Nagoya J Med Sci (2018)

Motor neuron cell-nonautonomous rescue of spinal muscular atrophy phenotypes in mild and severe transgenic mouse models

gan Hua, Yimin, Liu, Ying Hsiu, Sahashi, Kentaro, Rigo, Frank, Bennett, C. Frank, Krainer, Adrian R.
Cyhoeddwyd yn Genes Dev (2015)

Peripheral SMN restoration is essential for long-term rescue of a severe SMA mouse model

gan Hua, Yimin, Sahashi, Kentaro, Rigo, Frank, Hung, Gene, Horev, Guy, Bennett, C. Frank, Krainer, Adrian R.
Cyhoeddwyd 2011

Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model

gan Hua, Yimin, Sahashi, Kentaro, Hung, Gene, Rigo, Frank, Passini, Marco A., Bennett, C. Frank, Krainer, Adrian R.
Cyhoeddwyd 2010

In vitro and in silico analysis reveals an efficient algorithm to predict the splicing consequences of mutations at the 5′ splice sites

gan Sahashi, Kentaro, Masuda, Akio, Matsuura, Tohru, Shinmi, Jun, Zhang, Zhujun, Takeshima, Yasuhiro, Matsuo, Masafumi, Sobue, Gen, Ohno, Kinji
Cyhoeddwyd 2007

Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice

gan Sinha, Rahul, Kim, Young Jin, Nomakuchi, Tomoki, Sahashi, Kentaro, Hua, Yimin, Rigo, Frank, Bennett, C Frank, Krainer, Adrian R
Cyhoeddwyd yn Nucleic Acids Res (2018)

TSUNAMI: an antisense method to phenocopy splicing-associated diseases in animals

gan Sahashi, Kentaro, Hua, Yimin, Ling, Karen K.Y., Hung, Gene, Rigo, Frank, Horev, Guy, Katsuno, Masahisa, Sobue, Gen, Ko, Chien-Ping, Bennett, C. Frank, Krainer, Adrian R.
Cyhoeddwyd 2012

HMGCR antibody-associated myopathy as a paraneoplastic manifestation of esophageal carcinoma

gan Tsujikawa, Koyo, Hara, Kazuhiro, Muro, Yoshinao, Nakanishi, Hirotaka, Niwa, Yukiko, Koike, Masahiko, Noda, Seiya, Riku, Yuichi, Sahashi, Kentaro, Atsuta, Naoki, Ito, Mizuki, Shimoyama, Yoshie, Akiyama, Masashi, Katsuno, Masahisa
Cyhoeddwyd yn Neurology (2016)

DNA methylation inhibitor attenuates polyglutamine‐induced neurodegeneration by regulating Hes5

gan Kondo, Naohide, Tohnai, Genki, Sahashi, Kentaro, Iida, Madoka, Kataoka, Mayumi, Nakatsuji, Hideaki, Tsutsumi, Yutaka, Hashizume, Atsushi, Adachi, Hiroaki, Koike, Haruki, Shinjo, Keiko, Kondo, Yutaka, Sobue, Gen, Katsuno, Masahisa
Cyhoeddwyd yn EMBO Mol Med (2019)

Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS

gan Hirunagi, Tomoki, Sahashi, Kentaro, Tachikawa, Kiyoshi, Leu, Angel I., Nguyen, Michelle, Mukthavaram, Rajesh, Karmali, Priya P., Chivukula, Padmanabh, Tohnai, Genki, Iida, Madoka, Onodera, Kazunari, Ohyama, Manabu, Okada, Yohei, Okano, Hideyuki, Katsuno, Masahisa
Cyhoeddwyd yn Mol Ther Nucleic Acids (2021)

Pathological impact of SMN2 mis-splicing in adult SMA mice

gan Sahashi, Kentaro, Ling, Karen K Y, Hua, Yimin, Wilkinson, John Erby, Nomakuchi, Tomoki, Rigo, Frank, Hung, Gene, Xu, David, Jiang, Ya-Ping, Lin, Richard Z, Ko, Chien-Ping, Bennett, C Frank, Krainer, Adrian R
Cyhoeddwyd 2013

Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy

gan Iida, Madoka, Sahashi, Kentaro, Kondo, Naohide, Nakatsuji, Hideaki, Tohnai, Genki, Tsutsumi, Yutaka, Noda, Seiya, Murakami, Ayuka, Onodera, Kazunari, Okada, Yohei, Nakatochi, Masahiro, Tsukagoshi Okabe, Yuka, Shimizu, Shinobu, Mizuno, Masaaki, Adachi, Hiroaki, Okano, Hideyuki, Sobue, Gen, Katsuno, Masahisa
Cyhoeddwyd yn Nat Commun (2019)