DNA methylation inhibitor attenuates polyglutamine‐induced neurodegeneration by regulating Hes5

Spinal and bulbar muscular atrophy (SBMA) is a polyglutamine‐mediated neuromuscular disease caused by a CAG repeat expansion in the androgen receptor (AR) gene. While transcriptional dysregulation is known to play a critical role in the pathogenesis of SBMA, the underlying molecular pathomechanisms...

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Библиографические подробности
Опубликовано в: :EMBO Mol Med
Главные авторы: Kondo, Naohide, Tohnai, Genki, Sahashi, Kentaro, Iida, Madoka, Kataoka, Mayumi, Nakatsuji, Hideaki, Tsutsumi, Yutaka, Hashizume, Atsushi, Adachi, Hiroaki, Koike, Haruki, Shinjo, Keiko, Kondo, Yutaka, Sobue, Gen, Katsuno, Masahisa
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2019
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505579/
https://ncbi.nlm.nih.gov/pubmed/30940675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708547
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