Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease

Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease caused by the expansion of a trinucleotide CAG repeat encoding the polyglutamine tract in the first exon of the androgen receptor gene (AR). The pathogenic, polyglutamine-expanded AR protein accumulates in the cell nucl...

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Bibliographic Details
Main Authors: Katsuno, Masahisa, Sang, Chen, Adachi, Hiroaki, Minamiyama, Makoto, Waza, Masahiro, Tanaka, Fumiaki, Doyu, Manabu, Sobue, Gen
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1275598/
https://ncbi.nlm.nih.gov/pubmed/16260738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506249102
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