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Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease
Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease caused by the expansion of a trinucleotide CAG repeat encoding the polyglutamine tract in the first exon of the androgen receptor gene (AR). The pathogenic, polyglutamine-expanded AR protein accumulates in the cell nucl...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2005
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1275598/ https://ncbi.nlm.nih.gov/pubmed/16260738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506249102 |
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