Reversible Disruption of Dynactin 1-Mediated Retrograde Axonal Transport in Polyglutamine-Induced Motor Neuron Degeneration

Spinal and bulbar muscular atrophy (SBMA) is a hereditary neurodegenerative disease caused by an expansion of a trinucleotide CAG repeat encoding the polyglutamine tract in the androgen receptor (AR) gene. To elucidate the pathogenesis of polyglutamine-mediated motor neuron dysfunction, we investiga...

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Pubblicato in:J Neurosci
Autori principali: Katsuno, Masahisa, Adachi, Hiroaki, Minamiyama, Makoto, Waza, Masahiro, Tokui, Keisuke, Banno, Haruhiko, Suzuki, Keisuke, Onoda, Yu, Tanaka, Fumiaki, Doyu, Manabu, Sobue, Gen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675422/
https://ncbi.nlm.nih.gov/pubmed/17122035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3032-06.2006
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