Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

por McFarland, James M., Paolella, Brenton R., Warren, Allison, Geiger-Schuller, Kathryn, Shibue, Tsukasa, Rothberg, Michael, Kuksenko, Olena, Colgan, William N., Jones, Andrew, Chambers, Emily, Dionne, Danielle, Bender, Samantha, Wolpin, Brian M., Ghandi, Mahmoud, Tirosh, Itay, Rozenblatt-Rosen, Orit, Roth, Jennifer A., Golub, Todd R., Regev, Aviv, Aguirre, Andrew J., Vazquez, Francisca, Tsherniak, Aviad
Publicado no Nat Commun (2020)

Pan-cancer single cell RNA-seq uncovers recurring programs of cellular heterogeneity

por Kinker, Gabriela S., Greenwald, Alissa C., Tal, Rotem, Orlova, Zhanna, Cuoco, Michael S., McFarland, James M., Warren, Allison, Rodman, Christopher, Roth, Jennifer A., Bender, Samantha A., Kumar, Bhavna, Rocco, James W., Fernandes, Pedro ACM, Mader, Christopher C., Keren-Shaul, Hadas, Plotnikov, Alexander, Barr, Haim, Tsherniak, Aviad, Rozenblatt-Rosen, Orit, Krizhanovsky, Valery, Puram, Sidharth V., Regev, Aviv, Tirosh, Itay
Publicado no Nat Genet (2020)

Non-canonical open reading frames encode functional proteins essential for cancer cell survival

por Prensner, John R., Enache, Oana M., Luria, Victor, Krug, Karsten, Clauser, Karl R., Dempster, Joshua M., Karger, Amir, Wang, Li, Stumbraite, Karolina, Wang, Vickie M., Botta, Ginevra, Lyons, Nicholas J., Goodale, Amy, Kalani, Zohra, Fritchman, Briana, Brown, Adam, Alan, Douglas, Green, Thomas, Yang, Xiaoping, Jaffe, Jacob D., Roth, Jennifer A., Piccioni, Federica, Kirschner, Marc W., Ji, Zhe, Root, David E., Golub, Todd R.
Publicado no Nat Biotechnol (2021)

Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling

por Corsello, Steven M., Nagari, Rohith T., Spangler, Ryan D., Rossen, Jordan, Kocak, Mustafa, Bryan, Jordan G., Humeidi, Ranad, Peck, David, Wu, Xiaoyun, Tang, Andrew A., Wang, Vickie M., Bender, Samantha A., Lemire, Evan, Narayan, Rajiv, Montgomery, Philip, Ben-David, Uri, Garvie, Colin W., Chen, Yejia, Rees, Matthew G., Lyons, Nicholas J., McFarland, James M., Wong, Bang T., Wang, Li, Dumont, Nancy, O’Hearn, Patrick J., Stefan, Eric, Doench, John G., Harrington, Caitlin N., Greulich, Heidi, Meyerson, Matthew, Vazquez, Francisca, Subramanian, Aravind, Roth, Jennifer A., Bittker, Joshua A., Boehm, Jesse S., Mader, Christopher C., Tsherniak, Aviad, Golub, Todd R.
Publicado no Nat Cancer (2020)