Pan-cancer single cell RNA-seq uncovers recurring programs of cellular heterogeneity

Cultured cell lines are the workhorse of cancer research, but it is unclear to what extent they recapitulate the cellular heterogeneity observed among malignant cells in tumors. To address this, we used multiplexed single cell RNA-seq to profile ~200 cancer cell lines from 22 cancer types. We uncove...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Nat Genet
Κύριοι συγγραφείς: Kinker, Gabriela S., Greenwald, Alissa C., Tal, Rotem, Orlova, Zhanna, Cuoco, Michael S., McFarland, James M., Warren, Allison, Rodman, Christopher, Roth, Jennifer A., Bender, Samantha A., Kumar, Bhavna, Rocco, James W., Fernandes, Pedro ACM, Mader, Christopher C., Keren-Shaul, Hadas, Plotnikov, Alexander, Barr, Haim, Tsherniak, Aviad, Rozenblatt-Rosen, Orit, Krizhanovsky, Valery, Puram, Sidharth V., Regev, Aviv, Tirosh, Itay
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2020
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8135089/
https://ncbi.nlm.nih.gov/pubmed/33128048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00726-6
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