Pan-cancer single cell RNA-seq uncovers recurring programs of cellular heterogeneity

Cultured cell lines are the workhorse of cancer research, but it is unclear to what extent they recapitulate the cellular heterogeneity observed among malignant cells in tumors. To address this, we used multiplexed single cell RNA-seq to profile ~200 cancer cell lines from 22 cancer types. We uncove...

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Udgivet i:Nat Genet
Main Authors: Kinker, Gabriela S., Greenwald, Alissa C., Tal, Rotem, Orlova, Zhanna, Cuoco, Michael S., McFarland, James M., Warren, Allison, Rodman, Christopher, Roth, Jennifer A., Bender, Samantha A., Kumar, Bhavna, Rocco, James W., Fernandes, Pedro ACM, Mader, Christopher C., Keren-Shaul, Hadas, Plotnikov, Alexander, Barr, Haim, Tsherniak, Aviad, Rozenblatt-Rosen, Orit, Krizhanovsky, Valery, Puram, Sidharth V., Regev, Aviv, Tirosh, Itay
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8135089/
https://ncbi.nlm.nih.gov/pubmed/33128048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00726-6
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