Hypercapnic acidosis induces mitochondrial dysfunction and impairs the ability of mesenchymal stem cells to promote distal lung epithelial repair

Por Fergie, Nicola, Todd, Naomi, McClements, Lana, McAuley, Danny, O’Kane, Cecilia, Krasnodembskaya, Anna
Publicado no FASEB J (2019)

Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury

Por McAuley, Daniel F, O’Kane, Cecilia M, Craig, Thelma R, Shyamsundar, Murali, Herwald, Heiko, Dib, Karim
Publicado em 2013

Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials

Por Santhakumaran, Shalini, Gordon, Anthony, Prevost, A. Toby, O’Kane, Cecilia, McAuley, Daniel F., Shankar-Hari, Manu
Publicado no Crit Care (2019)

Prevention of post-operative complications by using a HMG-CoA reductase inhibitor in patients undergoing one-lung ventilation for non-cardiac surgery: study protocol for a randomis...

Por Shyamsundar, Murali, O’Kane, Cecilia, Perkins, Gavin D., Kennedy, Gavin, Campbell, Christina, Agus, Ashley, Phair, Glenn, McAuley, Danny
Publicado no Trials (2018)

STAT3, p38 MAPK, and NF-κB Drive Unopposed Monocyte-Dependent Fibroblast MMP-1 Secretion in Tuberculosis

Por O'Kane, Cecilia M., Elkington, Paul T., Jones, Michael D., Caviedes, Luz, Tovar, Marco, Gilman, Robert H., Stamp, Gordon, Friedland, Jon S.
Publicado em 2010

Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction – a randomised placebo-controlled trial (KARE): study protocol

Por Cross, Laurence JM, O’Kane, Cecilia M, McDowell, Cliona, Elborn, Jospeh J, Matthay, Michael A, McAuley, Daniel F
Publicado em 2013

A randomized clinical trial of ascorbic acid in open abdominal aortic aneurysm repair

Por Duffy, Martin J, O’Kane, Cecilia M, Stevenson, Michael, Young, Ian S, Harkin, Denis W, Mullan, Brian A, McAuley, Daniel F
Publicado no Intensive Care Med Exp (2015)

Erratum to: Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction – a randomised placebo-controlled trial (KARE): study protocol

Por Cross, Laurence J. M., O’Kane, Cecilia M., McDowell, Cliona, Elborn, Jospeh J., Matthay, Michael A., McAuley, Daniel F.
Publicado no Trials (2017)

Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer

Por Morrison, Thomas J., Jackson, Megan V., Cunningham, Erin K., Kissenpfennig, Adrien, McAuley, Daniel F., O’Kane, Cecilia M., Krasnodembskaya, Anna D.
Publicado no Am J Respir Crit Care Med (2017)

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction (HARP-2) trial: study protocol for a randomized controlled tria...

Por McAuley, Daniel F, Laffey, John G, O’Kane, Cecilia M, Cross, Mark, Perkins, Gavin D, Murphy, Lynn, McNally, Christine, Crealey, Grainne, Stevenson, Michael
Publicado em 2012

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS

Por Jackson, Megan V., Morrison, Thomas J., Doherty, Declan F., McAuley, Daniel F., Matthay, Michael A., Kissenpfennig, Adrien, O'Kane, Cecilia M., Krasnodembskaya, Anna D.
Publicado no Stem Cells (2016)

Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database

Por Boyle, Andrew J., Madotto, Fabiana, Laffey, John G., Bellani, Giacomo, Pham, Tài, Pesenti, Antonio, Thompson, B. Taylor, O’Kane, Cecilia M., Deane, Adam M., McAuley, Daniel F.
Publicado no Crit Care (2018)

ARDS Subphenotypes and Differential Response to Simvastatin: Secondary Analysis of a Randomized Controlled Trial

Por Calfee, Carolyn S., Delucchi, Kevin L., Sinha, Pratik, Matthay, Michael A., Hackett, Jonathan, Shankar-Hari, Manu, McDowell, Cliona, Laffey, John G., O’Kane, Cecilia M., McAuley, Daniel F.
Publicado no Lancet Respir Med (2018)

Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation

Por Moazed, Farzad, Burnham, Ellen .L., Vandivier, R. William, O’Kane, Cecilia M., Shyamsundar, Murali, Hamid, Umar, Abbott, Jason, Thickett, David R., Matthay, Michael. A., McAuley, Daniel F., Calfee, Carolyn S.
Publicado no Thorax (2016)

Keratinocyte Growth Factor Promotes Epithelial Survival and Resolution in a Human Model of Lung Injury

Por Shyamsundar, Murali, McAuley, Daniel F., Ingram, Rebecca J., Gibson, David S., O’Kane, Donal, McKeown, Scott T., Edwards, Alex, Taggart, Cliff, Elborn, Joseph S., Calfee, Carolyn S., Matthay, Michael A., O’Kane, Cecilia M.
Publicado no Am J Respir Crit Care Med (2014)

Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis

Por Boyle, Andrew J, Di Gangi, Stefania, Hamid, Umar I, Mottram, Linda-Jayne, McNamee, Lia, White, Griania, Cross, LJ Mark, McNamee, James J, O’Kane, Cecilia M, McAuley, Daniel F
Publicado no Crit Care (2015)

A Functional Variant of Elafin With Improved Anti-inflammatory Activity for Pulmonary Inflammation

Por Small, Donna M, Zani, Marie-Louise, Quinn, Derek J, Dallet-Choisy, Sandrine, Glasgow, Arlene MA, O'Kane, Cecilia, McAuley, Danny F, McNally, Paul, Weldon, Sinéad, Moreau, Thierry, Taggart, Clifford C
Publicado no Mol Ther (2015)

Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers

Por Shyamsundar, Murali, McKeown, Scott T. W., O'Kane, Cecilia M., Craig, Thelma R., Brown, Vanessa, Thickett, David R., Matthay, Michael A., Taggart, Clifford C., Backman, Janne T., Elborn, J. Stuart, McAuley, Daniel F.
Publicado em 2009

Respiratory Infections Cause the Release of Extracellular Vesicles: Implications in Exacerbation of Asthma/COPD

Por Eltom, Suffwan, Dale, Nicole, Raemdonck, Kristof R. G., Stevenson, Christopher S., Snelgrove, Robert J., Sacitharan, Pradeep K., Recchi, Chiara, Wavre-Shapton, Silene, McAuley, Daniel F., O'Kane, Cecilia, Belvisi, Maria G., Birrell, Mark A.
Publicado em 2014

Unexpected Role for Adaptive αβT(H)17 Cells in Acute Respiratory Distress Syndrome

Por Li, John T., Melton, Andrew C., Su, George, Hamm, David E., LaFemina, Michael, Howard, James, Fang, Xiaohui, Bhat, Sudarshan, Huynh, Kieu-My, O’Kane, Cecilia M., Ingram, Rebecca J., Muir, Roshell R., McAuley, Daniel F., Matthay, Michael A., Sheppard, Dean
Publicado no J Immunol (2015)