Erosion of Drug Margin Will Not Slow

Por O'Connell, Joseph
Publicado em 2007

Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 Å

Por Gruswitz, Franz, O'Connell, Joseph, Stroud, Robert M.
Publicado em 2007

Crystal Structure of the Human tRNA m (1)A58 Methyltransferase–tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target

Por Finer-Moore, Janet, Czudnochowski, Nadine, O'Connell, Joseph D., Wang, Amy Liya, Stroud, Robert M.
Publicado no J Mol Biol (2015)

Structural context shapes the aquaporin selectivity filter

Por Savage, David F., O’Connell, Joseph D., Miercke, Larry J. W., Finer-Moore, Janet, Stroud, Robert M.
Publicado em 2010

Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum

Por Newby, Zachary E R, O’Connell, Joseph, Robles-Colmenares, Yaneth, Khademi, Shahram, Miercke, Larry J, Stroud, Robert M
Publicado em 2008

Development and Binding Mode Assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutami...

Por Tochowicz, Anna, Dalziel, Sean, Eidam, Oliv, O’Connell, Joseph D., Griner, Sarah, Finer-Moore, Janet S., Stroud, Robert M.
Publicado em 2013

Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems

Por De Angelis, Fabien, Lee, John K., O'Connell, Joseph D., Miercke, Larry J. W., Verschueren, Koen H., Srinivasan, Vasundara, Bauvois, Cédric, Govaerts, Cédric, Robbins, Rebecca A., Ruysschaert, Jean-Marie, Stroud, Robert M., Vandenbussche, Guy
Publicado em 2010

Structures of intermediate transport states of ZneA, a Zn(II)/proton antiporter

Por Pak, John Edward, Ekendé, Elisabeth Ngonlong, Kifle, Efrem G., O’Connell, Joseph Daniel, De Angelis, Fabien, Tessema, Meseret B., Derfoufi, Kheiro-Mouna, Robles-Colmenares, Yaneth, Robbins, Rebecca A., Goormaghtigh, Erik, Vandenbussche, Guy, Stroud, Robert M.
Publicado em 2013

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

Por Monk, Brian C., Tomasiak, Thomas M., Keniya, Mikhail V., Huschmann, Franziska U., Tyndall, Joel D. A., O’Connell, Joseph D., Cannon, Richard D., McDonald, Jeffrey G., Rodriguez, Andrew, Finer-Moore, Janet S., Stroud, Robert M.
Publicado em 2014

Selecting Optimum Eukaryotic Integral Membrane Proteins for Structure Determination by Rapid Expression and Solubilization Screening

Por Li, Min, Hays, Franklin A., Roe-Zurz, Zygy, Vuong, Linda, Kelly, Libusha, Ho, Chi-Min, Robbins, Renée M., Pieper, Ursula, O’Connell, Joseph D., Miercke, Larry J. W., Giacomini, Kathleen M., Sali, Andrej, Stroud, Robert M.
Publicado em 2008

A phase 2 trial of dacomitinib (PF‐00299804), an oral, irreversible pan‐HER (human epidermal growth factor receptor) inhibitor, in patients with advanced non–small cell lung cancer...

Por Reckamp, Karen L., Giaccone, Giuseppe, Camidge, D. Ross, Gadgeel, Shirish M., Khuri, Fadlo R., Engelman, Jeff A., Koczywas, Marianna, Rajan, Arun, Campbell, Alicyn K., Gernhardt, Diana, Ruiz‐Garcia, Ana, Letrent, Stephen, Liang, Jane, Taylor, Ian, O'Connell, Joseph P., Jänne, Pasi A.
Publicado em 2014

Randomized Phase II Study of Dacomitinib (PF-00299804), an Irreversible Pan–Human Epidermal Growth Factor Receptor Inhibitor, Versus Erlotinib in Patients With Advanced Non–Small-C...

Por Ramalingam, Suresh S., Blackhall, Fiona, Krzakowski, Maciej, Barrios, Carlos H., Park, Keunchil, Bover, Isabel, Seog Heo, Dae, Rosell, Rafael, Talbot, Denis C., Frank, Richard, Letrent, Stephen P., Ruiz-Garcia, Ana, Taylor, Ian, Liang, Jane Q., Campbell, Alicyn K., O'Connell, Joseph, Boyer, Michael
Publicado no J Clin Oncol (2012)