Advances and Challenges in the Search for D(2) and D(3) Dopamine Receptor-Selective Compounds

Por Moritz, Amy E., Free, R. Benjamin, Sibley, David R.
Publicado no Cell Signal (2017)

Proline-directed phosphorylation of the dopamine transporter N-terminal domain

Por Gorentla, Balachandra K., Moritz, Amy E., Foster, James D., Vaughan, Roxanne A.
Publicado em 2009

Reciprocal Phosphorylation and Palmitoylation Control Dopamine Transporter Kinetics

Por Moritz, Amy E., Rastedt, Danielle E., Stanislowski, Daniel J., Shetty, Madhur, Smith, Margaret A., Vaughan, Roxanne A., Foster, James D.
Publicado no J Biol Chem (2015)

Phosphorylation of Dopamine Transporter Serine 7 Modulates Cocaine Analog Binding

Por Moritz, Amy E., Foster, James D., Gorentla, Balachandra K., Mazei-Robison, Michelle S., Yang, Jae-Won, Sitte, Harald H., Blakely, Randy D., Vaughan, Roxanne A.
Publicado em 2013

Dopamine Transporter Phosphorylation Site Threonine 53 Regulates Substrate Reuptake and Amphetamine-stimulated Efflux

Por Foster, James D., Yang, Jae-Won, Moritz, Amy E., ChallaSivaKanaka, Sathyavathi, Smith, Margaret A., Holy, Marion, Wilebski, Kyle, Sitte, Harald H., Vaughan, Roxanne A.
Publicado em 2012

Dopamine transporter phosphorylation site threonine 53 regulates substrate reuptake and amphetamine-stimulated efflux

Por Yang, Jae-Won, Foster, James D, Moritz, Amy E, ChallaSivaKanaka, Sathyavathi, Smith, Margaret A, Holy, Marion, Wilebski, Kyle, Vaughan, Roxanne A, Sitte, Harald H
Publicado em 2012

(−)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling

Por Meade, Julie A., Free, R. Benjamin, Miller, Nicole R., Chun, Lani S., Doyle, Trevor B., Moritz, Amy E., Conroy, Jennie L., Watts, Val J., Sibley, David R.
Publicado no Psychopharmacology (Berl) (2014)

Synthesis and pharmacological characterization of novel trans-cyclopropylmethyl-linked bivalent ligands that exhibit selectivity and allosteric pharmacology at the dopamine D(3) re...

Por Kumar, Vivek, Moritz, Amy E., Keck, Thomas M., Bonifazi, Alessandro, Ellenberger, Michael P., Sibley, Christopher D., Free, R. Benjamin, Shi, Lei, Lane, J. Robert, Sibley, David R., Newman, Amy Hauck
Publicado no J Med Chem (2017)

Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D(2) Dopamine Receptor

Por Chun, Lani S., Vekariya, Rakesh H., Free, R. Benjamin, Li, Yun, Lin, Da-Ting, Su, Ping, Liu, Fang, Namkung, Yoon, Laporte, Stephane A., Moritz, Amy E., Aubé, Jeffrey, Frankowski, Kevin J., Sibley, David R.
Publicado no Front Synaptic Neurosci (2018)

Investigation of the binding and functional properties of extended length D(3) dopamine receptor-selective antagonists()

Por Furman, Cheryse A., Roof, Rebecca A., Moritz, Amy E., Miller, Brittney N., Doyle, Trevor B., Free, R. Benjamin, Banala, Ashwini K., Paul, Noel M., Kumar, Vivek, Sibley, Christopher D., Newman, Amy Hauck, Sibley, David R.
Publicado no Eur Neuropsychopharmacol (2014)

Identification of Positive Allosteric Modulators of the D(1) Dopamine Receptor That Act at Diverse Binding Sites

Por Luderman, Kathryn D., Conroy, Jennie L., Free, R. Benjamin, Southall, Noel, Ferrer, Marc, Sanchez-Soto, Marta, Moritz, Amy E., Willette, Blair K. A., Fyfe, Tim J., Jain, Prashi, Titus, Steve, Hazelwood, Lisa A., Aubé, Jeffrey, Lane, J. Robert, Frankowski, Kevin J., Sibley, David R.
Publicado no Mol Pharmacol (2018)

Discovery and Characterization of a G Protein–Biased Agonist That Inhibits β-Arrestin Recruitment to the D2 Dopamine Receptor

Por Free, R. Benjamin, Chun, Lani S., Moritz, Amy E., Miller, Brittney N., Doyle, Trevor B., Conroy, Jennie L., Padron, Adrian, Meade, Julie A., Xiao, Jingbo, Hu, Xin, Dulcey, Andrés E., Han, Yang, Duan, Lihua, Titus, Steve, Bryant-Genevier, Melanie, Barnaeva, Elena, Ferrer, Marc, Javitch, Jonathan A., Beuming, Thijs, Shi, Lei, Southall, Noel T., Marugan, Juan J., Sibley, David R.
Publicado em 2014