Desmoteplase: discovery, insights and opportunities for ischaemic stroke

Por Medcalf, Robert L
Publicado em 2012

Improved Method for the Preparation of a Human Cell-based, Contact Model of the Blood-Brain Barrier

Por Niego, Be'eri, Medcalf, Robert L.
Publicado em 2013

Plasmin-dependent modulation of the blood–brain barrier: a major consideration during tPA-induced thrombolysis?

Por Niego, Be'eri, Medcalf, Robert L
Publicado em 2014

Editorial: The Role of the Plasminogen Activating System in Neurobiology

Por Medcalf, Robert L., Lawrence, Daniel A.
Publicado no Front Cell Neurosci (2016)

The relationship between the prothrombin upstream sequence element and the G20210A polymorphism: the influence of a competitive environment for mRNA 3′-end formation

Por Sachchithananthan, Mythily, Stasinopoulos, Stan J., Wilusz, Jeffrey, Medcalf, Robert L.
Publicado em 2005

Inhibition of interleukin 1β-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP

Por Hawkins, Christine J., Uren, Anthony G., Häcker, Georg, Medcalf, Robert L., Vaux, David L.
Publicado em 1996

Species-Specific Regulation of t-PA and PAI-1 Gene Expression in Human and Rat Astrocytes

Por Tjärnlund-Wolf, Anna, Hultman, Karin, Blomstrand, Fredrik, Nilsson, Michael, Medcalf, Robert L, Jern, Christina
Publicado em 2014

Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin

Por Niego, Be’eri, Lee, Natasha, Larsson, Pia, De Silva, T. Michael, Au, Amanda E-Ling, McCutcheon, Fiona, Medcalf, Robert L.
Publicado no PLoS One (2017)

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells

Por Samson, Andre L., Ho, Bosco, Au, Amanda E., Schoenwaelder, Simone M., Smyth, Mark J., Bottomley, Stephen P., Kleifeld, Oded, Medcalf, Robert L.
Publicado no Open Biol (2016)

Role of Histone Acetylation in the Stimulatory Effect of Valproic Acid on Vascular Endothelial Tissue-Type Plasminogen Activator Expression

Por Larsson, Pia, Ulfhammer, Erik, Magnusson, Mia, Bergh, Niklas, Lunke, Sebastian, El-Osta, Assam, Medcalf, Robert L., Svensson, Per-Arne, Karlsson, Lena, Jern, Sverker
Publicado em 2012

Identifying socio-demographic and socioeconomic determinants of health inequalities in a diverse London community: the South East London Community Health (SELCoH) study

Por Hatch, Stephani L, Frissa, Souci, Verdecchia, Maria, Stewart, Robert, Fear, Nicola T, Reichenberg, Abraham, Morgan, Craig, Kankulu, Bwalya, Clark, Jennifer, Gazard, Billy, Medcalf, Robert, Hotopf, Matthew
Publicado em 2011

Tissue-type plasminogen activator requires a co-receptor to enhance N-Methyl-D-Aspartate receptor function

Por Samson, Andre L., Nevin, Simon T., Croucher, David, Niego, Be’eri, Daniel, Philip B., Weiss, Thomas W., Moreno, Eliza, Monard, Denis, Lawrence, Daniel A., Medcalf, Robert L.
Publicado em 2008

Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single‐Chain Antibody Specific for Activated GPIIb/IIIa

Por Bonnard, Thomas, Tennant, Zachary, Niego, Be'Eri, Kanojia, Ruchi, Alt, Karen, Jagdale, Shweta, Law, Lok Soon, Rigby, Sheena, Medcalf, Robert Lindsay, Peter, Karlheinz, Hagemeyer, Christoph Eugen
Publicado no J Am Heart Assoc (2017)

Oxidation of an Exposed Methionine Instigates the Aggregation of Glyceraldehyde-3-phosphate Dehydrogenase

Por Samson, Andre L., Knaupp, Anja S., Kass, Itamar, Kleifeld, Oded, Marijanovic, Emilia M., Hughes, Victoria A., Lupton, Chris J., Buckle, Ashley M., Bottomley, Stephen P., Medcalf, Robert L.
Publicado em 2014

Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin

Por Borg, Rachael J., Samson, Andre L., Au, Amanda E.-L., Scholzen, Anja, Fuchsberger, Martina, Kong, Ying Y., Freeman, Roxann, Mifsud, Nicole A., Plebanski, Magdalena, Medcalf, Robert L.
Publicado no PLoS One (2015)

The Influence of Differentially Expressed Tissue-Type Plasminogen Activator in Experimental Autoimmune Encephalomyelitis: Implications for Multiple Sclerosis

Por Dahl, Lisa CM, Nasa, Zeyad, Chung, JieYu, Niego, Be’eri, Tarlac, Volga, Ho, Heidi, Galle, Adam, Petratos, Steven, Lee, Jae Young, Alderuccio, Frank, Medcalf, Robert L.
Publicado no PLoS One (2016)

Importance of Thinking Locally for Mental Health: Data from Cross-Sectional Surveys Representing South East London and England

Por Hatch, Stephani L., Woodhead, Charlotte, Frissa, Souci, Fear, Nicola T., Verdecchia, Maria, Stewart, Robert, Reichenberg, Abraham, Morgan, Craig, Bebbington, Paul, McManus, Sally, Brugha, Traolach, Kankulu, Bwalya, Clark, Jennifer L., Gazard, Billy, Medcalf, Robert, Hotopf, Matthew
Publicado em 2012

Tissue-Type Plasminogen Activator Regulates the Neuronal Uptake of Glucose in the Ischemic Brain

Por Wu, Fang, Wu, Jialing, Nicholson, Andrew D., Echeverry, Ramiro, Haile, Woldeab B., Catano, Marcela, An, Jie, Lee, Andrew K., Duong, Duc, Dammer, Eric B., Seyfried, Nicholas T., Tong, Frank C., Votaw, John R., Medcalf, Robert L., Yepes, Manuel
Publicado em 2012

The tissue-type plasminogen activator–plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans

Por Sashindranath, Maithili, Sales, Eunice, Daglas, Maria, Freeman, Roxann, Samson, Andre L., Cops, Elisa J., Beckham, Simone, Galle, Adam, McLean, Catriona, Morganti-Kossmann, Cristina, Rosenfeld, Jeffrey V., Madani, Rime, Vassalli, Jean-Dominique, Su, Enming J., Lawrence, Daniel A., Medcalf, Robert L.
Publicado em 2012

Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes

Por Crack, Peter J, Zhang, Moses, Morganti-Kossmann, Maria Cristina, Morris, Andrew J, Wojciak, Jonathan M, Fleming, Jonathan K, Karve, Ila, Wright, David, Sashindranath, Maithili, Goldshmit, Yona, Conquest, Alison, Daglas, Maria, Johnston, Leigh A, Medcalf, Robert L, Sabbadini, Roger A, Pébay, Alice
Publicado em 2014