The tissue-type plasminogen activator–plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans

The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in numerous brain pathologies including neurotrauma and ischaemic stroke. Tissue plasminogen activator is a serine protease that converts plasminogen t...

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Main Authors: Sashindranath, Maithili, Sales, Eunice, Daglas, Maria, Freeman, Roxann, Samson, Andre L., Cops, Elisa J., Beckham, Simone, Galle, Adam, McLean, Catriona, Morganti-Kossmann, Cristina, Rosenfeld, Jeffrey V., Madani, Rime, Vassalli, Jean-Dominique, Su, Enming J., Lawrence, Daniel A., Medcalf, Robert L.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501968/
https://ncbi.nlm.nih.gov/pubmed/22822039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/aws178
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