Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single‐Chain Antibody Specific for Activated GPIIb/IIIa

BACKGROUND: Thrombolytic therapy for acute thrombosis is limited by life‐threatening side effects such as major bleeding and neurotoxicity. New treatment options with enhanced fibrinolytic potential are therefore required. Here, we report the development of a new thrombolytic molecule that exploits...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Bonnard, Thomas, Tennant, Zachary, Niego, Be'Eri, Kanojia, Ruchi, Alt, Karen, Jagdale, Shweta, Law, Lok Soon, Rigby, Sheena, Medcalf, Robert Lindsay, Peter, Karlheinz, Hagemeyer, Christoph Eugen
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523756/
https://ncbi.nlm.nih.gov/pubmed/28159824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.004535
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