Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?

The ecto-nucleoside triphosphate diphosphohydrolase CD39 represents a promising antithrombotic therapeutic. It degrades adenosine 5′-diphosphate (ADP), a main platelet activating/recruiting agent. We hypothesized that delayed enrichment of CD39 on developing thrombi will allow for a low and safe sys...

詳細記述

保存先:
書誌詳細
主要な著者: Hohmann, Jan David, Wang, Xiaowei, Krajewski, Stefanie, Selan, Carly, Haller, Carolyn A., Straub, Andreas, Chaikof, Elliot L., Nandurkar, Harshal H., Hagemeyer, Christoph E., Peter, Karlheinz
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2013
主題:
Plenary Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630824/
https://ncbi.nlm.nih.gov/pubmed/23380744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-449694
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