Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?

The ecto-nucleoside triphosphate diphosphohydrolase CD39 represents a promising antithrombotic therapeutic. It degrades adenosine 5′-diphosphate (ADP), a main platelet activating/recruiting agent. We hypothesized that delayed enrichment of CD39 on developing thrombi will allow for a low and safe sys...

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Detalhes bibliográficos
Main Authors: Hohmann, Jan David, Wang, Xiaowei, Krajewski, Stefanie, Selan, Carly, Haller, Carolyn A., Straub, Andreas, Chaikof, Elliot L., Nandurkar, Harshal H., Hagemeyer, Christoph E., Peter, Karlheinz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630824/
https://ncbi.nlm.nih.gov/pubmed/23380744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-449694
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