TCF7L2: the biggest story in diabetes genetics since HLA?

Autor Zeggini, E., McCarthy, M. I.
Vydáno 2006

Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

Autor Southam, L., Soranzo, N., Montgomery, S. B., Frayling, T. M., McCarthy, M. I., Barroso, I., Zeggini, E.
Vydáno 2009

Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls

Autor Chinnery, P F, Mowbray, C, Patel, S K, Elson, J L, Sampson, M, Hitman, G A, McCarthy, M I, Hattersley, A T, Walker, M
Vydáno 2007

Apolipoprotein M can discriminate HNF1A-MODY from Type 1 diabetes

Autor Mughal, S. A., Park, R., Nowak, N., Gloyn, A. L., Karpe, F., Matile, H., Malecki, M. T., McCarthy, M. I., Stoffel, M., Owen, K. R.
Vydáno 2013

Study profile: the Durban Diabetes Study (DDS): a platform for chronic disease research

Autor Hird, T. R., Young, E. H., Pirie, F. J., Riha, J., Esterhuizen, T. M., O'Leary, B., McCarthy, M. I., Sandhu, M. S., Motala, A. A.
Vydáno v Glob Health Epidemiol Genom (2016)

Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes

Autor Edghill, E L, Khamis, A, Weedon, M N, Walker, M, Hitman, G A, McCarthy, M I, Owen, K R, Ellard, S, T Hattersley, A, Frayling, T M
Vydáno 2011

Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes

Autor Rafiq, S., Melzer, D., Weedon, M. N., Lango, H., Saxena, R., Scott, L. J., Palmer, C. N. A., Morris, A. D., McCarthy, M. I., Ferrucci, L., Hattersley, A. T., Zeggini, E., Frayling, T. M.
Vydáno 2008

A common biological basis of obesity and nicotine addiction

Autor Thorgeirsson, T E, Gudbjartsson, D F, Sulem, P, Besenbacher, S, Styrkarsdottir, U, Thorleifsson, G, Walters, G B, Furberg, H, Sullivan, P F, Marchini, J, McCarthy, M I, Steinthorsdottir, V, Thorsteinsdottir, U, Stefansson, K
Vydáno 2013

An association analysis of the HLA gene region in latent autoimmune diabetes in adults

Autor Desai, M., Zeggini, E., Horton, V. A., Owen, K. R., Hattersley, A. T., Levy, J. C., Walker, M., Gillespie, K. M., Bingley, P. J., Hitman, G. A., Holman, R. R., McCarthy, M. I., Clark, A.
Vydáno 2006

Genomewide Search for Type 2 Diabetes Mellitus Susceptibility Loci in Finnish Families: The Botnia Study

Autor Lindgren, C. M., Mahtani, M. M., Widén, E., McCarthy, M. I., Daly, M. J., Kirby, A., Reeve, M. P., Kruglyak, L., Parker, A., Meyer, J., Almgren, P., Lehto, M., Kanninen, T., Tuomi, T., Groop, L. C., Lander, E. S.
Vydáno 2002

Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes

Autor Herrera, B. M., Lockstone, H. E., Taylor, J. M., Ria, M., Barrett, A., Collins, S., Kaisaki, P., Argoud, K., Fernandez, C., Travers, M. E., Grew, J. P., Randall, J. C., Gloyn, A. L., Gauguier, D., McCarthy, M. I., Lindgren, C. M.
Vydáno 2010

H3Africa multi-centre study of the prevalence and environmental and genetic determinants of type 2 diabetes in sub-Saharan Africa: study protocol

Autor Ekoru, K., Young, E. H., Adebamowo, C., Balde, N., Hennig, B. J., Kaleebu, P., Kapiga, S., Levitt, N. S., Mayige, M., Mbanya, J. C., McCarthy, M. I., Nyan, O., Nyirenda, M., Oli, J., Ramaiya, K., Smeeth, L., Sobngwi, E., Rotimi, C. N., Sandhu, M. S., Motala, A. A.
Vydáno v Glob Health Epidemiol Genom (2016)

Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis

Autor Wojciechowski, P., Lipowska, A., Rys, P., Ewens, K. G., Franks, S., Tan, S., Lerchbaum, E., Vcelak, J., Attaoua, R., Straczkowski, M., Azziz, R., Barber, T. M., Hinney, A., Obermayer-Pietsch, B., Lukasova, P., Bendlova, B., Grigorescu, F., Kowalska, I., Goodarzi, M. O., Strauss, J. F., McCarthy, M. I., Malecki, M. T.
Vydáno 2012

Erratum to: Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis

Autor Wojciechowski, P., Lipowska, A., Rys, P., Ewens, K. G., Franks, S., Tan, S., Lerchbaum, E., Vcelak, J., Attaoua, R., Straczkowski, M., Azziz, R., Barber, T. M., Hinney, A., Obermayer-Pietsch, B., Lukasova, P., Bendlova, B., Grigorescu, F., Kowalska, I., Goodarzi, M. O., Strauss, J. F., McCarthy, M. I., Malecki, M. T.
Vydáno 2012

A role for coding functional variants in HNF4A in Type 2 Diabetes susceptibility

Autor Jafar-Mohammadi, B, Groves, C J, Gjesing, A P, Herrera, B M, Winckler, W, Stringham, H M, Morris, A P, Lauritzen, T, Doney, A S F, Morris, A D, Weedon, M N, Swift, A J, Kuusisto, J, Laakso, M, Altshuler, D, Hattersley, A T, Collins, F S, Boehnke, M, Hansen, T, Pedersen, O, Palmer, C N A, Frayling, T M, Gloyn, A L, McCarthy, M I
Vydáno 2010

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts

Autor van Leeuwen, N., Nijpels, G., Becker, M. L., Deshmukh, H., Zhou, K., Stricker, B. H. C., Uitterlinden, A. G., Hofman, A., van ’t Riet, E., Palmer, C. N. A., Guigas, B., Slagboom, P. E., Durrington, P., Calle, R. A., Neil, A., Hitman, G., Livingstone, S. J., Colhoun, H., Holman, R. R., McCarthy, M. I., Dekker, J. M., ’t Hart, L. M., Pearson, E. R.
Vydáno 2012

Genetic association analysis of LARS2 with type 2 diabetes

Autor Reiling, E., Jafar-Mohammadi, B., van ’t Riet, E., Weedon, M. N., van Vliet-Ostaptchouk, J. V., Hansen, T., Saxena, R., van Haeften, T. W., Arp, P. A., Das, S., Nijpels, G., Groenewoud, M. J., van Hove, E. C., Uitterlinden, A. G., Smit, J. W. A., Morris, A. D., Doney, A. S. F., Palmer, C. N. A., Guiducci, C., Hattersley, A. T., Frayling, T. M., Pedersen, O., Slagboom, P. E., Altshuler, D. M., Groop, L., Romijn, J. A., Maassen, J. A., Hofker, M. H., Dekker, J. M., McCarthy, M. I., ’t Hart, L. M.
Vydáno 2009

Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4

Autor Ma, R. C. W., Hu, C., Tam, C. H., Zhang, R., Kwan, P., Leung, T. F., Thomas, G. N., Go, M. J., Hara, K., Sim, X., Ho, J. S. K., Wang, C., Li, H., Lu, L., Wang, Y., Li, J. W., Wang, Y., Lam, V. K. L., Wang, J., Yu, W., Kim, Y. J., Ng, D. P., Fujita, H., Panoutsopoulou, K., Day-Williams, A. G., Lee, H. M., Ng, A. C. W., Fang, Y-J., Kong, A. P. S., Jiang, F., Ma, X., Hou, X., Tang, S., Lu, J., Yamauchi, T., Tsui, S. K. W., Woo, J., Leung, P. C., Zhang, X., Tang, N. L. S., Sy, H. Y., Liu, J., Wong, T. Y., Lee, J. Y., Maeda, S., Xu, G., Cherny, S. S., Chan, T. F., Ng, M. C. Y., Xiang, K., Morris, A. P., Keildson, S., Hu, R., Ji, L., Lin, X., Cho, Y. S., Kadowaki, T., Tai, E. S., Zeggini, E., McCarthy, M. I., Hon, K. L., Baum, L., Tomlinson, B., So, W. Y., Bao, Y., Chan, J. C. N., Jia, W.
Vydáno 2013

A novel highly-penetrant form of obesity due to microdeletions on chromosome 16p11.2

Autor Walters, R. G., Jacquemont, S., Valsesia, A., de Smith, A. J., Martinet, D., Andersson, J., Falchi, M., Chen, F., Andrieux, J., Lobbens, S., Delobel, B., Stutzmann, F., Moustafa, J. S. El-Sayed, Chèvre, J.-C., Lecoeur, C., Vatin, V., Bouquillon, S., Buxton, J. L., Boute, O., Holder-Espinasse, M., Cuisset, J.-M., Lemaitre, M.-P., Ambresin, A.-E., Brioshi, A., Gaillard, M., Giusti, V., Fellmann, F., Ferrarini, A., Hadjikhani, N., Campion, D., Guilmatre, A., Goldenberg, A., Calmels, N., Mandel, J.-L., Le Caignec, C., David, A., Isidor, B., Cordier, M.-P., Dupuis-Girod, S., Labalme, A., Sanlaville, D., Béri-Deixheimer, M., Jonveaux, P., Leheup, B., Õunap, K., Bochukova, E. G., Henning, E., Keogh, J., Ellis, R. J., MacDermot, K. D., Vincent-Delorme, C., Plessis, G., Touraine, R., Philippe, A., Malan, V., Mathieu-Dramard, M., Chiesa, J., Blaumeiser, B., Kooy, R. F., Caiazzo, R., Pigeyre, M., Balkau, B., Sladek, R., Bergmann, S., Mooser, V., Waterworth, D., Reymond, A., Vollenweider, P., Waeber, G., Kurg, A., Palta, P., Esko, T., Metspalu, A., Nelis, M., Elliott, P., Hartikainen, A.-L., McCarthy, M. I., Peltonen, L., Carlsson, L., Jacobson, P., Sjöström, L., Huang, N., Hurles, M. E., O’Rahilly, S., Farooqi, I. S., Männik, K., Jarvelin, M.-R., Pattou, F., Meyre, D., Walley, A. J., Coin, L. J. M., Blakemore, A. I. F., Froguel, P., Beckmann, J. S.
Vydáno 2010

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

Autor Albrechtsen, A., Grarup, N., Li, Y., Sparsø, T., Tian, G., Cao, H., Jiang, T., Kim, S. Y., Korneliussen, T., Li, Q., Nie, C., Wu, R., Skotte, L., Morris, A. P., Ladenvall, C., Cauchi, S., Stančáková, A., Andersen, G., Astrup, A., Banasik, K., Bennett, A. J., Bolund, L., Charpentier, G., Chen, Y., Dekker, J. M., Doney, A. S. F., Dorkhan, M., Forsen, T., Frayling, T. M., Groves, C. J., Gui, Y., Hallmans, G., Hattersley, A. T., He, K., Hitman, G. A., Holmkvist, J., Huang, S., Jiang, H., Jin, X., Justesen, J. M., Kristiansen, K., Kuusisto, J., Lajer, M., Lantieri, O., Li, W., Liang, H., Liao, Q., Liu, X., Ma, T., Ma, X., Manijak, M. P., Marre, M., Mokrosiński, J., Morris, A. D., Mu, B., Nielsen, A. A., Nijpels, G., Nilsson, P., Palmer, C. N. A., Rayner, N. W., Renström, F., Ribel-Madsen, R., Robertson, N., Rolandsson, O., Rossing, P., Schwartz, T. W., Slagboom, P. E., Sterner, M., Tang, M., Tarnow, L., Tuomi, T., van’t Riet, E., van Leeuwen, N., Varga, T. V., Vestmar, M. A., Walker, M., Wang, B., Wang, Y., Wu, H., Xi, F., Yengo, L., Yu, C., Zhang, X., Zhang, J., Zhang, Q., Zhang, W., Zheng, H., Zhou, Y., Altshuler, D., ‘t Hart, L. M., Franks, P. W., Balkau, B., Froguel, P., McCarthy, M. I., Laakso, M., Groop, L., Christensen, C., Brandslund, I., Lauritzen, T., Witte, D. R., Linneberg, A., Jørgensen, T., Hansen, T., Wang, J., Nielsen, R., Pedersen, O.
Vydáno 2012