Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes

AIM: Genome-wide association studies have identified > 30 common variants associated with Type 2 diabetes (> 5% minor allele frequency). These variants have small effects on individual risk and do not account for a large proportion of the heritable component of the disease. Monogenic forms of...

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Hlavní autoři: Edghill, E L, Khamis, A, Weedon, M N, Walker, M, Hitman, G A, McCarthy, M I, Owen, K R, Ellard, S, T Hattersley, A, Frayling, T M
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2011
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586655/
https://ncbi.nlm.nih.gov/pubmed/21569088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1464-5491.2011.03269.x
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