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Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

AIMS/HYPOTHESIS: According to the thrifty genotype hypothesis, the high prevalence of type 2 diabetes and obesity is a consequence of genetic variants that have undergone positive selection during historical periods of erratic food supply. The recent expansion in the number of validated type 2 diabe...

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Autors principals: Southam, L., Soranzo, N., Montgomery, S. B., Frayling, T. M., McCarthy, M. I., Barroso, I., Zeggini, E.
Format: Artigo
Idioma:Inglês
Publicat: Springer-Verlag 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723682/
https://ncbi.nlm.nih.gov/pubmed/19526209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-009-1419-3
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