Revisiting the Thrifty Gene Hypothesis via 65 Loci Associated with Susceptibility to Type 2 Diabetes

We have investigated the evidence for positive selection in samples of African, European, and East Asian ancestry at 65 loci associated with susceptibility to type 2 diabetes (T2D) previously identified through genome-wide association studies. Selection early in human evolutionary history is predict...

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Main Authors: Ayub, Qasim, Moutsianas, Loukas, Chen, Yuan, Panoutsopoulou, Kalliope, Colonna, Vincenza, Pagani, Luca, Prokopenko, Inga, Ritchie, Graham R.S., Tyler-Smith, Chris, McCarthy, Mark I., Zeggini, Eleftheria, Xue, Yali
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928649/
https://ncbi.nlm.nih.gov/pubmed/24412096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2013.12.010
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