Structural and Biochemical Insights into the Peptidoglycan Hydrolase Domain of FlgJ from Salmonella typhimurium

Por Zaloba, Patryk, Bailey-Elkin, Ben A., Derksen, Miriam, Mark, Brian L.
Publicado no PLoS One (2016)

Inactivation of the Glycoside Hydrolase NagZ Attenuates Antipseudomonal β-Lactam Resistance in Pseudomonas aeruginosa

Por Asgarali, Azizah, Stubbs, Keith A., Oliver, Antonio, Vocadlo, David J., Mark, Brian L.
Publicado em 2009

Viral OTU Deubiquitinases: A Structural and Functional Comparison

Por Bailey-Elkin, Ben A., van Kasteren, Puck B., Snijder, Eric J., Kikkert, Marjolein, Mark, Brian L.
Publicado em 2014

Crystal Structure of Human β-Hexosaminidase B: Understanding the Molecular Basis of Sandhoff and Tay–Sachs Disease

Por Mark, Brian L., Mahuran, Don J., Cherney, Maia M., Zhao, Dalian, Knapp, Spencer, James, Michael N. G.
Publicado em 2003

Crystallographic Structure of Human β-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of G(M2) Ganglioside Hydrolysis

Por Lemieux, M. Joanne, Mark, Brian L., Cherney, Maia M., Withers, Stephen G., Mahuran, Don J., James, Michael N. G.
Publicado em 2006

AmpG Inactivation Restores Susceptibility of Pan-β-Lactam-Resistant Pseudomonas aeruginosa Clinical Strains

Por Zamorano, Laura, Reeve, Thomas M., Juan, Carlos, Moyá, Bartolomé, Cabot, Gabriel, Vocadlo, David J., Mark, Brian L., Oliver, Antonio
Publicado em 2011

Insight into a strategy for attenuating AmpC-mediated β-lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZ

Por Balcewich, Misty D, Stubbs, Keith A, He, Yuan, James, Terrence W, Davies, Gideon J, Vocadlo, David J, Mark, Brian L
Publicado em 2009

In Cellulo Examination of a Beta-Alpha Hybrid Construct of Beta-Hexosaminidase A Subunits, Reported to Interact with the GM2 Activator Protein and Hydrolyze GM2 Ganglioside

Por Sinici, Incilay, Yonekawa, Sayuri, Tkachyova, Ilona, Gray, Steven J., Samulski, R. Jude, Wakarchuk, Warren, Mark, Brian L., Mahuran, Don J.
Publicado em 2013

Conformational Itinerary of Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase during Its Catalytic Cycle

Por Bacik, John-Paul, Tavassoli, Marjan, Patel, Trushar R., McKenna, Sean A., Vocadlo, David J., Khajehpour, Mazdak, Mark, Brian L.
Publicado em 2014

Producing Glucose 6-Phosphate from Cellulosic Biomass: STRUCTURAL INSIGHTS INTO LEVOGLUCOSAN BIOCONVERSION

Por Bacik, John-Paul, Klesmith, Justin R., Whitehead, Timothy A., Jarboe, Laura R., Unkefer, Clifford J., Mark, Brian L., Michalczyk, Ryszard
Publicado no J Biol Chem (2015)

NagZ Inactivation Prevents and Reverts β-Lactam Resistance, Driven by AmpD and PBP 4 Mutations, in Pseudomonas aeruginosa

Por Zamorano, Laura, Reeve, Thomas M., Deng, Lehua, Juan, Carlos, Moyá, Bartolomé, Cabot, Gabriel, Vocadlo, David J., Mark, Brian L., Oliver, Antonio
Publicado em 2010

Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease

Por James, Terrence W., Frias-Staheli, Natalia, Bacik, John-Paul, Levingston Macleod, Jesica M., Khajehpour, Mazdak, García-Sastre, Adolfo, Mark, Brian L.
Publicado em 2011

The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to β-Lactams

Por Stubbs, Keith A, Bacik, John-Paul, Perley-Robertson, G Evan, Whitworth, Garrett E, Gloster, Tracey M, Vocadlo, David J, Mark, Brian L
Publicado em 2013

Construction of a hybrid β-hexosaminidase subunit capable of forming stable homodimers that hydrolyze GM2 ganglioside in vivo

Por Tropak, Michael B, Yonekawa, Sayuri, Karumuthil-Melethil, Subha, Thompson, Patrick, Wakarchuk, Warren, Gray, Steven J, Walia, Jagdeep S, Mark, Brian L, Mahuran, Don
Publicado no Mol Ther Methods Clin Dev (2016)

Molecular Basis of 1,6-Anhydro Bond Cleavage and Phosphoryl Transfer by Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase

Por Bacik, John-Paul, Whitworth, Garrett E., Stubbs, Keith A., Yadav, Anuj K., Martin, Dylan R., Bailey-Elkin, Ben A., Vocadlo, David J., Mark, Brian L.
Publicado em 2011

Platelet Hexosaminidase A Enzyme Assay Effectively Detects Carriers Missed by Targeted DNA Mutation Analysis

Por Nakagawa, Sachiko, Zhan, Jie, Sun, Wei, Ferreira, Jose Carlos, Keiles, Steven, Hambuch, Tina, Kammesheidt, Anja, Mark, Brian L., Schneider, Adele, Gross, Susan, Schreiber-Agus, Nicole
Publicado em 2012

The β-Lactamase Gene Regulator AmpR Is a Tetramer That Recognizes and Binds the d-Ala-d-Ala Motif of Its Repressor UDP-N-acetylmuramic Acid (MurNAc)-pentapeptide

Por Vadlamani, Grishma, Thomas, Misty D., Patel, Trushar R., Donald, Lynda J., Reeve, Thomas M., Stetefeld, Jörg, Standing, Kenneth G., Vocadlo, David J., Mark, Brian L.
Publicado no J Biol Chem (2015)

Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells

Por van Kasteren, Puck B., Bailey-Elkin, Ben A., James, Terrence W., Ninaber, Dennis K., Beugeling, Corrine, Khajehpour, Mazdak, Snijder, Eric J., Mark, Brian L., Kikkert, Marjolein
Publicado em 2013

Novel Vector Design and Hexosaminidase Variant Enabling Self-Complementary Adeno-Associated Virus for the Treatment of Tay-Sachs Disease

Por Karumuthil-Melethil, Subha, Kalburgi, Sahana Nagabhushan, Thompson, Patrick, Tropak, Michael, Kaytor, Michael D., Keimel, John G., Mark, Brian L., Mahuran, Don, Walia, Jagdeep S., Gray, Steven J.
Publicado no Hum Gene Ther (2016)

Experimental mapping of soluble protein domains using a hierarchical approach

Por Pedelacq, Jean-Denis, Nguyen, Hau B., Cabantous, Stephanie, Mark, Brian L., Listwan, Pawel, Bell, Carolyn, Friedland, Natasha, Lockard, Meghan, Faille, Alexandre, Mourey, Lionel, Terwilliger, Thomas C., Waldo, Geoffrey S.
Publicado em 2011