AmpG Inactivation Restores Susceptibility of Pan-β-Lactam-Resistant Pseudomonas aeruginosa Clinical Strains

Constitutive AmpC hyperproduction is the most frequent mechanism of resistance to the weak AmpC inducers antipseudomonal penicillins and cephalosporins. Previously, we demonstrated that inhibition of the β-N-acetylglucosaminidase NagZ prevents and reverts this mechanism of resistance, which is cause...

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Autores principales: Zamorano, Laura, Reeve, Thomas M., Juan, Carlos, Moyá, Bartolomé, Cabot, Gabriel, Vocadlo, David J., Mark, Brian L., Oliver, Antonio
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2011
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088256/
https://ncbi.nlm.nih.gov/pubmed/21357303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01688-10
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