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Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease

The attachment of ubiquitin (Ub) and the Ub-like (Ubl) molecule interferon-stimulated gene 15 (ISG15) to cellular proteins mediates important innate antiviral responses. Ovarian tumor (OTU) domain proteases from nairoviruses and arteriviruses were recently found to remove these molecules from host p...

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Detalhes bibliográficos
Main Authors: James, Terrence W., Frias-Staheli, Natalia, Bacik, John-Paul, Levingston Macleod, Jesica M., Khajehpour, Mazdak, García-Sastre, Adolfo, Mark, Brian L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038750/
https://ncbi.nlm.nih.gov/pubmed/21245344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013388108
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