In Cellulo Examination of a Beta-Alpha Hybrid Construct of Beta-Hexosaminidase A Subunits, Reported to Interact with the GM2 Activator Protein and Hydrolyze GM2 Ganglioside

The hydrolysis in lysosomes of GM2 ganglioside to GM3 ganglioside requires the correct synthesis, intracellular assembly and transport of three separate gene products; i.e., the alpha and beta subunits of heterodimeric beta-hexosaminidase A, E.C. # 3.2.1.52 (encoded by the HEXA and HEXB genes, respe...

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Detalhes bibliográficos
Main Authors: Sinici, Incilay, Yonekawa, Sayuri, Tkachyova, Ilona, Gray, Steven J., Samulski, R. Jude, Wakarchuk, Warren, Mark, Brian L., Mahuran, Don J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587417/
https://ncbi.nlm.nih.gov/pubmed/23483939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057908
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