Therapeutic Targeting of the IGF Axis

af Osher, Eliot, Macaulay, Valentine M.
Udgivet i Cells (2019)

Can we unlock the potential of IGF-1R inhibition in cancer therapy?

af King, Helen, Aleksic, Tamara, Haluska, Paul, Macaulay, Valentine M.
Udgivet 2014

Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of β-catenin

af Playford, Martin P., Bicknell, David, Bodmer, Walter F., Macaulay, Valentine M.
Udgivet 2000

Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies

af Simpson, Aaron, Petnga, Wilfride, Macaulay, Valentine M., Weyer-Czernilofsky, Ulrike, Bogenrieder, Thomas
Udgivet i Target Oncol (2017)

Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition

af Lodhia, Kunal A, Gao, Shan, Aleksic, Tamara, Esashi, Fumiko, Macaulay, Valentine M
Udgivet i Int J Cancer (2015)

IGF-1R nuclear import and recruitment to chromatin involves both alpha and beta subunits

af Mills, Jack V., Osher, Eliot, Rieunier, Guillaume, Mills, Ian G., Macaulay, Valentine M.
Udgivet i Discov Oncol (2021)

RAPTOR up-regulation contributes to resistance of renal cancer cells to PI3K-mTOR inhibition

af Earwaker, Philip, Anderson, Caroline, Willenbrock, Frances, Harris, Adrian L., Protheroe, Andrew S., Macaulay, Valentine M.
Udgivet i PLoS One (2018)

IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination

af Chitnis, Meenali M., Lodhia, Kunal A., Aleksic, Tamara, Gao, Shan, Protheroe, Andrew S., Macaulay, Valentine M.
Udgivet 2013

Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma

af Simpson, Aaron D., Soo, Ying Wei Jenetta, Rieunier, Guillaume, Aleksic, Tamara, Ansorge, Olaf, Jones, Chris, Macaulay, Valentine M.
Udgivet i Br J Cancer (2019)

Type 1 IGF receptor translocates to the nucleus of human tumor cells

af Aleksic, Tamara, Chitnis, Meenali M., Perestenko, Olga V., Gao, Shan, Thomas, Peter H., Turner, Gareth D., Protheroe, Andrew S., Howarth, Mark, Macaulay, Valentine M.
Udgivet 2010

Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR

af Aleksic, Tamara, Browning, Lisa, Woodward, Martha, Phillips, Rachel, Page, Suzanne, Henderson, Shirley, Athanasou, Nicholas, Ansorge, Olaf, Whitwell, Duncan, Pratap, Sarah, Hassan, A. Bassim, Middleton, Mark R., Macaulay, Valentine M.
Udgivet i Front Oncol (2016)

Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors

af Macaulay, Valentine M., Middleton, Mark R., Eckhardt, S. Gail, Rudin, Charles M., Juergens, Rosalyn A., Gedrich, Richard, Gogov, Sven, McCarthy, Sean, Poondru, Srinivasu, Stephens, Andrew W., Gadgeel, Shirish M.
Udgivet i Clin Cancer Res (2016)

IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer

af Aleksic, Tamara, Verrill, Clare, Bryant, Richard J, Han, Cheng, Worrall, Andrew Ross, Brureau, Laurent, Larré, Stephane, Higgins, Geoff S, Fazal, Fahad, Sabbagh, Ahmad, Haider, Syed, Buffa, Francesca M, Cole, David, Macaulay, Valentine M
Udgivet i Br J Cancer (2017)

IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide

af Ramcharan, Roger, Aleksic, Tamara, Kamdoum, Wilfride Petnga, Gao, Shan, Pfister, Sophia X., Tanner, Jordan, Bridges, Esther, Asher, Ruth, Watson, Amanda J., Margison, Geoffrey P., Woodcock, Mick, Repapi, Emmanouela, Li, Ji-Liang, Middleton, Mark R., Macaulay, Valentine M.
Udgivet i Oncotarget (2015)

Nuclear IGF-1R interacts with regulatory regions of chromatin to promote RNA polymerase II recruitment and gene expression associated with advanced tumor stage

af Aleksic, Tamara, Gray, Nicki, Wu, Xiaoning, Rieunier, Guillaume, Osher, Eliot, Mills, Jack, Verrill, Clare, Bryant, Richard J., Han, Cheng, Hutchinson, Kathryn, Lambert, Adam G., Kumar, Rajeev, Hamdy, Freddie C., Weyer-Czernilofsky, Ulrike, Sanderson, Michael P., Bogenrieder, Thomas, Taylor, Stephen, Macaulay, Valentine M.
Udgivet i Cancer Res (2018)

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

af Pfister, Sophia X., Markkanen, Enni, Jiang, Yanyan, Sarkar, Sovan, Woodcock, Mick, Orlando, Giulia, Mavrommati, Ioanna, Pai, Chen-Chun, Zalmas, Lykourgos-Panagiotis, Drobnitzky, Neele, Dianov, Grigory L., Verrill, Clare, Macaulay, Valentine M., Ying, Songmin, La Thangue, Nicholas B., D’Angiolella, Vincenzo, Ryan, Anderson J., Humphrey, Timothy C.
Udgivet i Cancer Cell (2015)