Nuclear IGF-1R interacts with regulatory regions of chromatin to promote RNA polymerase II recruitment and gene expression associated with advanced tumor stage

Internalization of ligand-activated type 1 IGF receptor (IGF-1R) is followed by recycling to the plasma membrane, degradation or nuclear translocation. Nuclear IGF-1R reportedly associates with clinical response to IGF-1R inhibitory drugs, yet its role in the nucleus is poorly characterized. Here we...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Aleksic, Tamara, Gray, Nicki, Wu, Xiaoning, Rieunier, Guillaume, Osher, Eliot, Mills, Jack, Verrill, Clare, Bryant, Richard J., Han, Cheng, Hutchinson, Kathryn, Lambert, Adam G., Kumar, Rajeev, Hamdy, Freddie C., Weyer-Czernilofsky, Ulrike, Sanderson, Michael P., Bogenrieder, Thomas, Taylor, Stephen, Macaulay, Valentine M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031306/
https://ncbi.nlm.nih.gov/pubmed/29735545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-3498
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