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IGF-1R nuclear import and recruitment to chromatin involves both alpha and beta subunits
Mature type 1 insulin-like growth factor receptors (IGF-1Rs) are heterotetrameric structures comprising two extracellular α-subunits disulphide-bonded to two transmembrane β-subunits with tyrosine kinase activity. IGF-1R is a well-known cell surface mediator of malignant growth, with an incompletely...
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| Publicado no: | Discov Oncol |
|---|---|
| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8084799/ https://ncbi.nlm.nih.gov/pubmed/33969359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12672-021-00407-8 |
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