IGF-1R nuclear import and recruitment to chromatin involves both alpha and beta subunits

Mature type 1 insulin-like growth factor receptors (IGF-1Rs) are heterotetrameric structures comprising two extracellular α-subunits disulphide-bonded to two transmembrane β-subunits with tyrosine kinase activity. IGF-1R is a well-known cell surface mediator of malignant growth, with an incompletely...

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Gardado en:
Detalles Bibliográficos
Publicado en:Discov Oncol
Main Authors: Mills, Jack V., Osher, Eliot, Rieunier, Guillaume, Mills, Ian G., Macaulay, Valentine M.
Formato: Artigo
Idioma:Inglês
Publicado: Springer US 2021
Assuntos:
Brief Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8084799/
https://ncbi.nlm.nih.gov/pubmed/33969359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12672-021-00407-8
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