Antihelminthic benzimidazoles potentiate navitoclax (ABT-263) activity by inducing Noxa-dependent apoptosis in non-small cell lung cancer (NSCLC) cell lines

Por Lam, Lloyd T, Zhang, Haichao, Xue, John, Leverson, Joel D, Bhathena, Anahita
Publicado no Cancer Cell Int (2015)

Genomic analysis and selective small molecule inhibition identifies BCL-X(L) as a critical survival factor in a subset of colorectal cancer

Por Zhang, Haichao, Xue, John, Hessler, Paul, Tahir, Stephen K., Chen, Jun, Jin, Sha, Souers, Andrew J., Leverson, Joel D., Lam, Lloyd T.
Publicado no Mol Cancer (2015)

Potential mechanisms of resistance to venetoclax and strategies to circumvent it

Por Tahir, Stephen K., Smith, Morey L., Hessler, Paul, Rapp, Lisa Roberts, Idler, Kenneth B., Park, Chang H., Leverson, Joel D., Lam, Lloyd T.
Publicado no BMC Cancer (2017)

Compensatory IKKα activation of classical NF-κB signaling during IKKβ inhibition identified by an RNA interference sensitization screen

Por Lam, Lloyd T., Davis, R. Eric, Ngo, Vu N., Lenz, Georg, Wright, George, Xu, Weihong, Zhao, Hong, Yu, Xin, Dang, Lenny, Staudt, Louis M.
Publicado em 2008

Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-κB pathways in subtypes of diffuse large B-cell lymphoma

Por Lam, Lloyd T., Wright, George, Davis, R. Eric, Lenz, Georg, Farinha, Pedro, Dang, Lenny, Chan, John W., Rosenwald, Andreas, Gascoyne, Randy D., Staudt, Louis M.
Publicado em 2008

A mechanistic rationale for MEK inhibitor therapy in myeloma based on blockade of MAF oncogene expression

Por Annunziata, Christina M., Hernandez, Lidia, Davis, R. Eric, Zingone, Adriana, Lamy, Laurence, Lam, Lloyd T., Hurt, Elaine M., Shaffer, Arthur L., Kuehl, W. Michael, Staudt, Louis M.
Publicado em 2011

Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol

Por Lam, Lloyd T, Pickeral, Oxana K, Peng, Amy C, Rosenwald, Andreas, Hurt, Elaine M, Giltnane, Jena M, Averett, Lauren M, Zhao, Hong, Davis, R Eric, Sathyamoorthy, Mohan, Wahl, Larry M, Harris, Eric D, Mikovits, Judy A, Monks, Anne P, Hollingshead, Melinda G, Sausville, Edward A, Staudt, Louis M
Publicado em 2001

Statins enhance efficacy of venetoclax in blood cancers

Por Lee, J. Scott, Roberts, Andrew, Juarez, Dennis, Vo, Thanh-Trang T., Bhatt, Shruti, Herzog, Lee-or, Mallya, Sharmila, Bellin, Richard J., Agarwal, Suresh K., Salem, Ahmed Hamed, Xu, Tu, Jia, Jia, Li, Lingxiao, Hanna, John R., Davids, Matthew S., Fleischman, Angela G., O’Brien, Susan, Lam, Lloyd T., Leverson, Joel D., Letai, Anthony, Schatz, Jonathan H., Fruman, David A.
Publicado no Sci Transl Med (2018)

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways

Por Lenz, Georg, Wright, George W., Emre, N. C. Tolga, Kohlhammer, Holger, Dave, Sandeep S., Davis, R. Eric, Carty, Shannon, Lam, Lloyd T., Shaffer, A. L., Xiao, Wenming, Powell, John, Rosenwald, Andreas, Ott, German, Muller-Hermelink, Hans Konrad, Gascoyne, Randy D., Connors, Joseph M., Campo, Elias, Jaffe, Elaine S., Delabie, Jan, Smeland, Erlend B., Rimsza, Lisa M., Fisher, Richard I., Weisenburger, Dennis D., Chan, Wing C., Staudt, Louis M.
Publicado em 2008

Discovery of a potent catalytic p300/CBP inhibitor that targets lineage-specific tumors

Por Lasko, Loren M., Jakob, Clarissa G., Edalji, Rohinton P., Qiu, Wei, Montgomery, Debra, Digiammarino, Enrico L., Hansen, T. Matt, Risi, Roberto M., Frey, Robin, Manaves, Vlasios, Shaw, Bailin, Algire, Mikkel, Hessler, Paul, Lam, Lloyd T., Uziel, Tamar, Faivre, Emily, Ferguson, Debra, Buchanan, Fritz G., Martin, Ruth L., Torrent, Maricel, Chiang, Gary G., Karukurichi, Kannan, Langston, J. William, Weinert, Brian T., Choudhary, Chunaram, de Vries, Peter, Van Drie, John H., McElligott, David, Kesicki, Ed, Marmorstein, Ronen, Sun, Chaohong, Cole, Philip A., Rosenberg, Saul H., Michaelides, Michael R., Lai, Albert, Bromberg, Kenneth D.
Publicado no Nature (2017)