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Compensatory IKKα activation of classical NF-κB signaling during IKKβ inhibition identified by an RNA interference sensitization screen

A subtype of diffuse large B-cell lymphoma (DLBCL), termed activated B-cell-like (ABC) DLBCL, depends on constitutive nuclear factor-κB (NF-κB) signaling for survival. Small molecule inhibitors of IκB kinase β (IKKβ), a key regulator of the NF-κB pathway, kill ABC DLBCL cells and hold promise for th...

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Bibliografiske detaljer
Main Authors: Lam, Lloyd T., Davis, R. Eric, Ngo, Vu N., Lenz, Georg, Wright, George, Xu, Weihong, Zhao, Hong, Yu, Xin, Dang, Lenny, Staudt, Louis M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634958/
https://ncbi.nlm.nih.gov/pubmed/19104039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806491106
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