Antihelminthic benzimidazoles potentiate navitoclax (ABT-263) activity by inducing Noxa-dependent apoptosis in non-small cell lung cancer (NSCLC) cell lines

BACKGROUND: Evasion of apoptosis is a hallmark of cancer cells. One mechanism to deregulate the apoptotic pathway is by upregulation of the anti-apoptotic Bcl-2 family members. Navitoclax (ABT-263) is a Bcl-2/Bcl-x(L) inhibitor that restores the ability of cancer cells to undergo apoptosis. METHODS:...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cancer Cell Int
Asıl Yazarlar: Lam, Lloyd T, Zhang, Haichao, Xue, John, Leverson, Joel D, Bhathena, Anahita
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2015
Konular:
Primary Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326508/
https://ncbi.nlm.nih.gov/pubmed/25685063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-014-0151-3
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller