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Antihelminthic benzimidazoles potentiate navitoclax (ABT-263) activity by inducing Noxa-dependent apoptosis in non-small cell lung cancer (NSCLC) cell lines
BACKGROUND: Evasion of apoptosis is a hallmark of cancer cells. One mechanism to deregulate the apoptotic pathway is by upregulation of the anti-apoptotic Bcl-2 family members. Navitoclax (ABT-263) is a Bcl-2/Bcl-x(L) inhibitor that restores the ability of cancer cells to undergo apoptosis. METHODS:...
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| Publicado no: | Cancer Cell Int |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4326508/ https://ncbi.nlm.nih.gov/pubmed/25685063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-014-0151-3 |
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