OXIDATIVE STRESS AND TREG DEPLETION IN LUPUS PATIENTS WITH ANTI-PHOSPHOLIPID SYNDROME

Por Lai, Zhi-wei, Marchena-Mendez, Ivan, Perl, Andras
Publicado no Clin Immunol (2015)

Attention Deficit and Hyperactivity Disorder Scores Are Elevated and Respond to N-Acetylcysteine Treatment in Patients With Systemic Lupus Erythematosus

Por Garcia, Ricardo J., Francis, Lisa, Dawood, Maha, Lai, Zhi-wei, Faraone, Stephen V., Perl, Andras
Publicado em 2013

Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic targ...

Por Perl, Andras, Hanczko, Robert, Lai, Zhi-Wei, Oaks, Zachary, Kelly, Ryan, Borsuk, Rebecca, Asara, John M., Phillips, Paul E.
Publicado no Metabolomics (2015)

Identification of Stage-Specific Gene Modulation during Early Thymocyte Development by Whole-Genome Profiling Analysis after Aryl Hydrocarbon Receptor Activation

Por Laiosa, Michael D., Mills, Jeffrey H., Lai, Zhi-Wei, Singh, Kameshwar P., Middleton, Frank A., Gasiewicz, Thomas A., Silverstone, Allen E.
Publicado em 2010

MTOR ACTIVATION TRIGGERS IL-4 PRODUCTION AND NECROTIC DEATH OF DOUBLE-NEGATIVE T CELLS IN PATIENTS WITH SYSTEMIC LUPUS ERYHTHEMATOSUS

Por Lai, Zhi-Wei, Borsuk, Rebecca, Shadakshari, Ashwini, Yu, Jianghong, Dawood, Maha, Garcia, Ricardo, Francis, Lisa, Tily, Hajra, Bartos, Adam, Faraone, Stephen V., Phillips, Paul, Perl, Andras
Publicado em 2013

mTOR activation triggers proinflammatory expansion of IL-4-producing and necrosis-prone double-negative T cells, precedes flares, and serves as target for treatment in patients wit...

Por Lai, Zhi-Wei, Borsuk, Rebecca, Shadakshari, Ashwini, Yu, Jianghong, Dawood, Maha, Garcia, Ricardo, Francis, Lisa, Tily, Hajra, Bartos, Adam, Faraone, Stephen V, Phillips, Paul, Perl, Andras
Publicado em 2014

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

Por Lai, Zhi-Wei, Kelly, Ryan, Winans, Thomas, Marchena, Ivan, Shadakshari, Ashwini, Yu, Julie, Dawood, Maha, Garcia, Ricardo, Tily, Hajra, Francis, Lisa, Faraone, Stephen V, Phillips, Paul E, Perl, Andras
Publicado no Lancet (2018)

HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE

Por Caza, Tiffany N, Fernandez, David R, Talaber, Gergely, Oaks, Zachary, Haas, Mark, Madaio, Michael P, Lai, Zhi-wei, Miklossy, Gabriella, Singh, Ram R, Chudakov, Dmitriy M, Malorni, Walter, Middleton, Frank, Banki, Katalin, Perl, Andras
Publicado em 2014

N-ACETYLCYSTEINE REDUCES DISEASE ACTIVITY BY BLOCKING MTOR IN T CELLS OF LUPUS PATIENTS

Por Lai, Zhi-Wei, Hanczko, Robert, Bonilla, Eduardo, Caza, Tiffany N., Clair, Brandon, Bartos, Adam, Miklossy, Gabriella, Jimah, John, Doherty, Edward, Tily, Hajra, Francis, Lisa, Garcia, Ricardo, Dawood, Maha, Yu, Jianghong, Ramos, Irene, Coman, Ioana, Faraone, Stephen V., Phillips, Paul E., Perl, Andras
Publicado em 2012