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Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

BACKGROUND: Patients with systemic lupus erythematosus have T-cell dysfunction that has been attributed to the activation of the mammalian target of rapamycin (mTOR). Rapamycin inhibits antigen-induced T-cell proliferation and has been developed as a medication under the generic designation of sirol...

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Dades bibliogràfiques
Publicat a:Lancet
Autors principals: Lai, Zhi-Wei, Kelly, Ryan, Winans, Thomas, Marchena, Ivan, Shadakshari, Ashwini, Yu, Julie, Dawood, Maha, Garcia, Ricardo, Tily, Hajra, Francis, Lisa, Faraone, Stephen V, Phillips, Paul E, Perl, Andras
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891154/
https://ncbi.nlm.nih.gov/pubmed/29551338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(18)30485-9
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