MTOR ACTIVATION TRIGGERS IL-4 PRODUCTION AND NECROTIC DEATH OF DOUBLE-NEGATIVE T CELLS IN PATIENTS WITH SYSTEMIC LUPUS ERYHTHEMATOSUS

The mechanistic target of rapamycin (mTOR) is recognized as a sensor of mitochondrial dysfunction and effector of T-cell lineage development, however, its role in autoimmunity, including systemic lupus erythematosus, remains unclear. Here, we prospectively evaluated mitochondrial dysfunction and mTO...

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Detalhes bibliográficos
Main Authors: Lai, Zhi-Wei, Borsuk, Rebecca, Shadakshari, Ashwini, Yu, Jianghong, Dawood, Maha, Garcia, Ricardo, Francis, Lisa, Tily, Hajra, Bartos, Adam, Faraone, Stephen V., Phillips, Paul, Perl, Andras
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777662/
https://ncbi.nlm.nih.gov/pubmed/23913957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301005
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