N-ACETYLCYSTEINE REDUCES DISEASE ACTIVITY BY BLOCKING MTOR IN T CELLS OF LUPUS PATIENTS

BACKGROUND: Systemic lupus erythematosus (SLE) patients exhibit T-cell dysfunction which can be regulated through the mitochondrial transmembrane potential (Δψ(m)) and mammalian target of rapamycin (mTOR) by glutathione. Therefore, the safety, tolerance, and efficacy of glutathione-precursor N-acety...

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Autores principales: Lai, Zhi-Wei, Hanczko, Robert, Bonilla, Eduardo, Caza, Tiffany N., Clair, Brandon, Bartos, Adam, Miklossy, Gabriella, Jimah, John, Doherty, Edward, Tily, Hajra, Francis, Lisa, Garcia, Ricardo, Dawood, Maha, Yu, Jianghong, Ramos, Irene, Coman, Ioana, Faraone, Stephen V., Phillips, Paul E., Perl, Andras
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411859/
https://ncbi.nlm.nih.gov/pubmed/22549432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34502
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