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N-ACETYLCYSTEINE REDUCES DISEASE ACTIVITY BY BLOCKING MTOR IN T CELLS OF LUPUS PATIENTS

BACKGROUND: Systemic lupus erythematosus (SLE) patients exhibit T-cell dysfunction which can be regulated through the mitochondrial transmembrane potential (Δψ(m)) and mammalian target of rapamycin (mTOR) by glutathione. Therefore, the safety, tolerance, and efficacy of glutathione-precursor N-acety...

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Detalhes bibliográficos
Main Authors: Lai, Zhi-Wei, Hanczko, Robert, Bonilla, Eduardo, Caza, Tiffany N., Clair, Brandon, Bartos, Adam, Miklossy, Gabriella, Jimah, John, Doherty, Edward, Tily, Hajra, Francis, Lisa, Garcia, Ricardo, Dawood, Maha, Yu, Jianghong, Ramos, Irene, Coman, Ioana, Faraone, Stephen V., Phillips, Paul E., Perl, Andras
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411859/
https://ncbi.nlm.nih.gov/pubmed/22549432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34502
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