HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE

OBJECTIVE: Accumulation of mitochondria underlies T-cell dysfunction in systemic lupus erythematosus (SLE). Mitochondrial turnover involves endosomal traffic regulated by HRES-1/Rab4, a small GTPase that is overexpressed in lupus T cells. Therefore, we investigated whether (1) HRES-1/Rab4 impacts mi...

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Detalhes bibliográficos
Main Authors: Caza, Tiffany N, Fernandez, David R, Talaber, Gergely, Oaks, Zachary, Haas, Mark, Madaio, Michael P, Lai, Zhi-wei, Miklossy, Gabriella, Singh, Ram R, Chudakov, Dmitriy M, Malorni, Walter, Middleton, Frank, Banki, Katalin, Perl, Andras
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2014
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047212/
https://ncbi.nlm.nih.gov/pubmed/23897774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2013-203794
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