Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation

Overexpression and long terminal repeat (LTR) polymorphism of the HRES‑1/Rab4 human endogenous retrovirus locus have been associated with T cell activation and disease manifestations in systemic lupus erythematosus (SLE). Although genomic DNA methylation is diminished overall in SLE, its role in HRE...

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Publicado en:JCI Insight
Autores principales: Godavarthy, Aparna, Kelly, Ryan, Jimah, John, Beckford, Miguel, Caza, Tiffany, Fernandez, David, Huang, Nick, Duarte, Manuel, Lewis, Joshua, Fadel, Hind J., Poeschla, Eric M., Banki, Katalin, Perl, Andras
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7030820/
https://ncbi.nlm.nih.gov/pubmed/31805010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134010
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