Activation of mTOR controls the loss of TCRζ in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation

Persistent mitochondrial hyperpolarization (MHP) and enhanced calcium fluxing underlie aberrant T-cell activation and death pathway selection in systemic lupus erythematosus. Treatment with rapamycin, which effectively controls disease activity, normalizes CD3/CD28-induced calcium fluxing but fails...

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Main Authors: Fernandez, David R., Telarico, Tiffany, Bonilla, Eduardo, Li, Qing, Banerjee, Sanjay, Middleton, Frank A., Phillips, Paul E., Crow, Mary K., Oess, Stefanie, Muller-Esterl, Werner, Perl, Andras
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676112/
https://ncbi.nlm.nih.gov/pubmed/19201859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803600
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