Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease

Por Rajamohan, Francis, Reyes, Allan R., Tu, Meihua, Nedoma, Nicole L., Hoth, Lise R., Schwaid, Adam G., Kurumbail, Ravi G., Ward, Jessica, Han, Seungil
Publicado no J Lipid Res (2020)

Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system

Por Caspers, Nicole L., Han, Seungil, Rajamohan, Francis, Hoth, Lise R., Geoghegan, Kieran F., Subashi, Timothy A., Vazquez, Michael L., Kaila, Neelu, Cronin, Ciarán N., Johnson, Eric, Kurumbail, Ravi G.
Publicado no Acta Crystallogr F Struct Biol Commun (2016)

Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological a...

Por Rajamohan, Francis, Reyes, Allan R., Frisbie, Richard K., Hoth, Lise R., Sahasrabudhe, Parag, Magyar, Rachelle, Landro, James A., Withka, Jane M., Caspers, Nicole L., Calabrese, Matthew F., Ward, Jessica, Kurumbail, Ravi G.
Publicado no Biochem J (2016)

Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery

Por Bernard-Gauthier, Vadim, Mossine, Andrew V., Knight, Ashley, Patnaik, Debasis, Zhao, Wen-Ning, Cheng, Chialin, Krishnan, Hema S., Xuan, Lucius L., Chindavong, Peter S., Reis, Surya A., Chen, Jinshan Michael, Shao, Xia, Stauff, Jenelle, Arteaga, Janna, Sherman, Phillip, Salem, Nicolas, Bonsall, David, Amaral, Brenda, Varlow, Cassis, Wells, Lisa, Martarello, Laurent, Patel, Shil, Liang, Steven H., Kurumbail, Ravi G., Haggarty, Stephen J., Scott, Peter J. H., Vasdev, Neil
Publicado no J Med Chem (2019)

Discovery of a highly selective glycogen synthase kinase-3 inhibitor (PF-04802367) that modulates tau phosphorylation in brain: Translation for PET neuroimaging

Por Liang, Steven H., Chen, Jinshan Michael, Normandin, Marc D., Chang, Jeanne S., Chang, George C., Taylor, Christine K., Trapa, Patrick, Plummer, Mark S., Para, Kimberly S., Conn, Edward L., Lopresti-Morrow, Lori, Lanyon, Lorraine F., Cook, James M., Richter, Karl E. G., Nolan, Charlie E., Schachter, Joel B., Janat, Fouad, Che, Ye, Shanmugasundaram, Veerabahu, Lefker, Bruce A., Enerson, Bradley E., Livni, Elijahu, Wang, Lu, Guehl, Nicolas, Patnaik, Debasis, Wagner, Florence F., Perlis, Roy, Holson, Edward B., Haggarty, Stephen J., Fakhri, Georges El, Kurumbail, Ravi G., Vasdev, Neil
Publicado no Angew Chem Int Ed Engl (2016)