NOVEL METABOLOMICS MARKERS PREDICT 18-MONTH DECLINE IN HAND GRIP STRENGTH IN COMMUNITY-DWELLING OLDER ADULTS

Por Siang Ng, Ted Kheng, Kovalik, Jean-Paul, Ching, Jianhong, Chan, Angelique, Matchar, David
Publicado no Innov Aging (2019)

The acute transcriptional responses to dietary methionine restriction are triggered by inhibition of ternary complex formation and linked to Erk1/2, mTOR, and ATF4

Por Stone, Kirsten P., Ghosh, Sujoy, Kovalik, Jean Paul, Orgeron, Manda, Wanders, Desiree, Sims, Landon C., Gettys, Thomas W.
Publicado no Sci Rep (2021)

Comprehensive assessment of insulin resistance in non‐obese Asian Indian and Chinese men

Por Tan, Hong Chang, Yew, Tong Wei, Chacko, Shaji, Tai, E Shyong, Kovalik, Jean‐Paul, Ching, Jianhong, Myo Thant, Sandi, Khoo, Chin Meng
Publicado no J Diabetes Investig (2018)

Characterization of a primary brown adipocyte culture system derived from human fetal interscapular fat

Por Seiler, Sarah E, Xu, Dan, Ho, Jia-Pei, Lo, Kinyui Alice, Buehrer, Benjamin M, Ludlow, Y John W, Kovalik, Jean-Paul, Sun, Lei
Publicado no Adipocyte (2015)

Serum acylcarnitines and amino acids and risk of type 2 diabetes in a multiethnic Asian population

Por Gunther, Samuel H, Khoo, Chin Meng, Tai, E-Shyong, Sim, Xueling, Kovalik, Jean-Paul, Ching, Jianhong, Lee, Jeannette J, van Dam, Rob M
Publicado no BMJ Open Diabetes Res Care (2020)

Associations of Bariatric Interventions With Micronutrient and Endocrine Disturbances

Por Syn, Nicholas L., Lee, Phong Ching, Kovalik, Jean-Paul, Tham, Kwang Wei, Ong, Hock Soo, Chan, Weng Hoong, Tan, Chuen Seng, Lim, Chin Hong
Publicado no JAMA Netw Open (2020)

Resolution of Erosive Esophagitis After Conversion from Vertical Sleeve Gastrectomy to Roux-en-Y Gastric Bypass

Por Lim, Chin Hong, Lee, Phong Ching, Lim, Eugene, Eng, Alvin, Chan, Weng Hoong, Tan, Hong Chang, Ho, Emily, Kovalik, Jean-Paul, Ganguly, Sonali, Tan, Jeremy
Publicado no Obes Surg (2020)

Proximal Tubular Cell–Specific Ablation of Carnitine Acetyltransferase Causes Tubular Disease and Secondary Glomerulosclerosis

Por Kruger, Claudia, Nguyen, Trang-Tiffany, Breaux, Chelsea, Guillory, Alana, Mangelli, Margaret, Fridianto, Kevin T., Kovalik, Jean-Paul, Burk, David H., Noland, Robert C., Mynatt, Randall, Stadler, Krisztian
Publicado no Diabetes (2019)

Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation

Por Shin, Kyung Cheul, Hwang, Injae, Choe, Sung Sik, Park, Jeu, Ji, Yul, Kim, Jong In, Lee, Gha Young, Choi, Sung Hee, Ching, Jianhong, Kovalik, Jean-Paul, Kim, Jae Bum
Publicado no Nat Commun (2017)

Profiling of Plasma Metabolites Suggests Altered Mitochondrial Fuel Usage and Remodeling of Sphingolipid Metabolism in Individuals With Type 2 Diabetes and Kidney Disease

Por Liu, Jian-Jun, Ghosh, Sujoy, Kovalik, Jean-Paul, Ching, Jianhong, Choi, Hyung Won, Tavintharan, Subramaniam, Ong, Choon Nam, Sum, Chee Fang, Summers, Scott A., Tai, E. Shyong, Lim, Su Chi
Publicado no Kidney Int Rep (2016)

Dissecting Clinical and Metabolomics Associations of Left Atrial Phasic Function by Cardiac Magnetic Resonance Feature Tracking

Por Koh, Angela S., Gao, Fei, Leng, Shuang, Kovalik, Jean-Paul, Zhao, Xiaodan, Tan, Ru San, Fridianto, Kevin Timothy, Ching, Jianhong, Chua, Serene JM, Yuan, Jian-Min, Koh, Woon-Puay, Zhong, Liang
Publicado no Sci Rep (2018)

Metabolic Remodeling of Human Skeletal Myocytes by Cocultured Adipocytes Depends on the Lipolytic State of the System

Por Kovalik, Jean-Paul, Slentz, Dorothy, Stevens, Robert D., Kraus, William E., Houmard, Joseph A., Nicoll, James B., Lea-Currie, Y. Renee, Everingham, Karen, Kien, C. Lawrence, Buehrer, Benjamin M., Muoio, Deborah M.
Publicado em 2011

Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse...

Por Ohba, Kenji, Sinha, Rohit Anthony, Singh, Brijesh Kumar, Iannucci, Liliana Felicia, Zhou, Jin, Kovalik, Jean-Paul, Liao, Xiao-Hui, Refetoff, Samuel, Sng, Judy Chia Ghee, Leow, Melvin Khee-Shing, Yen, Paul Michael
Publicado no Thyroid (2017)

Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta

Por Teo, Emelyne, Ravi, Sudharshan, Barardo, Diogo, Kim, Hyung-Seok, Fong, Sheng, Cazenave-Gassiot, Amaury, Tan, Tsze Yin, Ching, Jianhong, Kovalik, Jean-Paul, Wenk, Markus R, Gunawan, Rudiyanto, Moore, Philip K, Halliwell, Barry, Tolwinski, Nicholas, Gruber, Jan
Publicado no eLife (2019)

Metabolomic correlates of aerobic capacity among elderly adults

Por Koh, Angela S., Gao, Fei, Tan, Ru S., Zhong, Liang, Leng, Shuang, Zhao, Xiaodan, Fridianto, Kevin T., Ching, Jianhong, Lee, Si Y., Keng, Bryan M. H., Yeo, Tee Joo, Tan, Shu Y., Tan, Hong C., Lim, Chin T., Koh, Woon‐Puay, Kovalik, Jean‐Paul
Publicado no Clin Cardiol (2018)

MicroRNAs Are Required for the Feature Maintenance and Differentiation of Brown Adipocytes

Por Kim, Hye-Jin, Cho, Hyunjii, Alexander, Ryan, Patterson, Heide Christine, Gu, Minxia, Lo, Kinyui Alice, Xu, Dan, Goh, Vera J., Nguyen, Long N., Chai, Xiaoran, Huang, Cher X., Kovalik, Jean-Paul, Ghosh, Sujoy, Trajkovski, Mirko, Silver, David L., Lodish, Harvey, Sun, Lei
Publicado no Diabetes (2014)

Muscle-specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility

Por Muoio, Deborah M., Noland, Robert C., Kovalik, Jean-Paul, Seiler, Sarah E., Davies, Michael N., DeBalsi, Karen L., Ilkayeva, Olga R., Stevens, Robert D., Kheterpal, Indu, Zhang, Jingying, Covington, Jeffrey D., Bajpeyi, Sudip, Ravussin, Eric, Kraus, William, Koves, Timothy R., Mynatt, Randall L.
Publicado em 2012

Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction

Por de Carvalho, Leonardo P., Tan, Sock Hwee, Ow, Ghim-Siong, Tang, Zhiqun, Ching, Jianhong, Kovalik, Jean-Paul, Poh, Sock Cheng, Chin, Chee-Tang, Richards, A. Mark, Martinez, Eliana C., Troughton, Richard W., Fong, Alan Yean-Yip, Yan, Bryan P., Seneviratna, Aruni, Sorokin, Vitaly, Summers, Scott A., Kuznetsov, Vladimir A., Chan, Mark Y.
Publicado no JACC Basic Transl Sci (2018)

BCL6 promotes glioma and serves as a therapeutic target

Por Xu, Liang, Chen, Ye, Dutra-Clarke, Marina, Mayakonda, Anand, Hazawa, Masaharu, Savinoff, Steve E., Doan, Ngan, Said, Jonathan W., Yong, William H., Watkins, Ashley, Yang, Henry, Ding, Ling-Wen, Jiang, Yan-Yi, Tyner, Jeffrey W., Ching, Jianhong, Kovalik, Jean-Paul, Madan, Vikas, Chan, Shing-Leng, Müschen, Markus, Breunig, Joshua J., Lin, De-Chen, Koeffler, H. Phillip
Publicado no Proc Natl Acad Sci U S A (2017)

Titin truncating variants affect heart function in disease cohorts and the general population

Por Schafer, Sebastian, de Marvao, Antonio, Adami, Eleonora, Fiedler, Lorna R, Ng, Benjamin, Khin, Ester, Rackham, Owen J L, van Heesch, Sebastiaan, Pua, Chee J, Kui, Miao, Walsh, Roddy, Tayal, Upasana, Prasad, Sanjay K, Dawes, Timothy J W, Ko, Nicole S J, Sim, David, Chan, Laura L, Chin, Calvin W L, Mazzarotto, Francesco, Barton, Paul J, Kreuchwig, Franziska, de Kleijn, Dominique P V, Totman, Teresa, Biffi, Carlo, Tee, Nicole, Rueckert, Daniel, Schneider, Valentin, Faber, Allison, Regitz-Zagrosek, Vera, Seidman, Jonathan G, Seidman, Christine E, Linke, Wolfgang A, Kovalik, Jean-Paul, O’Regan, Declan Patrick, Ware, James S, Hubner, Norbert, Cook, Stuart A
Publicado no Nat Genet (2016)