Activation of oxidative stress response in cancer generates a druggable dependency on exogenous non-essential amino acids

door LeBoeuf, Sarah E., Wu, Warren L., Karakousi, Triantafyllia R., Karadal, Burcu, Jackson, S. RaElle, Davidson, Shawn M., Wong, Kwok-kin, Koralov, Sergei B., Sayin, Volkan I., Papagiannakopoulos, Thales
Gepubliceerd in Cell Metab (2019)

Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1

door Lignitto, Luca, LeBoeuf, Sarah E., Homer, Harrison, Jiang, Shaowen, Askenazi, Manor, Karakousi, Triantafyllia R., Pass, Harvey I., Bhutkar, Arjun J., Tsirigos, Aristotelis, Ueberheide, Beatrix, Sayin, Volkan I., Papagiannakopoulos, Thales, Pagano, Michele
Gepubliceerd in Cell (2019)

Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase Epsilon

door Sviderskiy, Vladislav O., Blumenberg, Lili, Gorodetsky, Elizabeth, Karakousi, Triantafyllia R., Hirsh, Nicole, Alvarez, Samantha W., Terzi, Erdem M., Kaparos, Efiyenia, Whiten, Gabrielle C., Ssebyala, Shakirah, Tonzi, Peter, Mir, Hannan, Neel, Benjamin G., Huang, Tony T., Adams, Sylvia, Ruggles, Kelly V., Possemato, Richard
Gepubliceerd in Mol Cell (2020)

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

door Sayin, Volkan I, LeBoeuf, Sarah E, Singh, Simranjit X, Davidson, Shawn M, Biancur, Douglas, Guzelhan, Betul S, Alvarez, Samantha W, Wu, Warren L, Karakousi, Triantafyllia R, Zavitsanou, Anastasia Maria, Ubriaco, Julian, Muir, Alexander, Karagiannis, Dimitris, Morris, Patrick J, Thomas, Craig J, Possemato, Richard, Vander Heiden, Matthew G, Papagiannakopoulos, Thales
Gepubliceerd in eLife (2017)

Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis

door Romero, Rodrigo, Sayin, Volkan I., Davidson, Shawn M., Bauer, Matthew R., Singh, Simranjit X., LeBoeuf, Sarah E., Karakousi, Triantafyllia R., Ellis, Donald C., Bhutkar, Arjun, Sanchez-Rivera, Francisco J., Subbaraj, Lakshmipriya, Martinez, Britney, Bronson, Roderick T., Prigge, Justin R., Schmidt, Edward E., Thomas, Craig J., Goparaju, Chandra, Davies, Angela, Dolgalev, Igor, Heguy, Adriana, Allaj, Viola, Poirier, John T., Moreira, Andre L., Rudin, Charles M., Pass, Harvey I., Vander Heiden, Matthew G., Jacks, Tyler, Papagiannakopoulos, Thales
Gepubliceerd in Nat Med (2017)